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Alison Wendlandt, an Assistant Professor of Chemistry at the Massachusetts Institute of Technology, talks to Nature Synthesis about how hydrogen atom transfer can be used to selectively edit C(sp3)–H bonds in sugars and polyols.
Timothy Noël, a professor at the University of Amsterdam and Chair of Flow Chemistry, talks to Nature Synthesis about how flow technologies and photocatalytic methods enable C(sp3)–H functionalization reactions.
The use of step count as a metric of synthetic efficiency carries opportunities and challenges. Here, proposals are made to standardize what constitutes a synthetic step and how steps are counted. These proposals may be beneficial in the holistic evaluation of published synthetic routes.
