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Cellular metabolism has emerged as a major biological node governing cellular behaviour. In their review, Boon et al. explore the mechanisms that maintain nuclear metabolic compartmentalization and the regulation of epigenetics, cell fate and cell physiology by nuclear metabolism.
Franco et al, review how metabolic insufficiency and prolonged stress responses impact signaling cascades and epigenetic reprogramming to lock T cells into an exhausted state.
Exercise is a powerful modifier of organismal, tissue and cellular metabolism. In their Review, Koelwyn et al. highlight how exercise-induced alterations in the tumour microenvironment can affect immunometabolic mechanisms and how these changes may contribute to the benefits of exercise on cancer initiation and progression.
Kusuyama et al. review the effects of maternal and paternal exercise on offspring metabolic health in adulthood, the time of life when metabolic diseases typically surface.
Cellular metabolic demand skyrockets during intense exercise, thus rendering the communication of metabolic state essential for organismal homeostasis. Murphy, Watt and Febbraio discuss the physiological processes governing intertissue communication during exercise and the molecules mediating such cross-talk.
Hargreaves and Spriet review regulatory mechanisms of ATP resynthesis during exercise and summarize nutritional interventions that target muscle metabolism to enhance athletic performance.
Frampton et al. review emerging understanding of how the three primary gut-derived short-chain fatty acids—acetate, propionate and butyrate—affect skeletal muscle metabolism and function.
Childhood obesity is one of the most serious public-health challenges of this century. Here, Caprio et al. provide a Review encompassing several aspects of childhood obesity, including epidemiology, genetic and environmental contributions, and cardiometabolic complications.
Xu and colleagues provide a comprehensive overview of cholesterol metabolism in cancer cells and its effects on immune cells of the tumour microenvironment, highlighting its effects on cancer growth as well as opportunities for therapeutic intervention.
