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Volume 2 Issue 3, March 2021

Network nutrition

Network medicine utilizes the power of data science to explore functionally relevant cellular interactions in the progression of disease, offering insights for the development of improved pharmaceutical targets. Polyphenols are phytochemicals found across a variety of food sources and though their health benefits, particularly in protection against non-communicable chronic disease, are increasingly observed in epidemiology, the molecular mechanisms by which these benefits are conferred are poorly established. A network medicine framework allows the cellular interconnectedness of polyphenol protein targets and proteins associated with disease to be explored. The network proximity of these target and disease neighbours of the human interactome is shown to be predictive of therapeutic effects of polyphenols.

See do Valle et al.

Image: nehopelon / Alamy Stock Photo. Cover Design: Tulsi Voralia.

Editorial

  • Nutrition is a relatively young and evolving science. Political will to reform food systems can be shown by shepherding nutritional science towards population priorities and preventing its commodification.

    Editorial

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Comment & Opinion

  • Global food systems are not fit for human and planetary health. Pessimism is easy, but does not ignite positive change. This critical moment calls for visions that are optimistic, principled and actionable, argues Roy Steiner.

    • Roy Steiner
    World View
  • Different framings of food may shape food policies and their impact. Despite acknowledging food systems’ complexities, the European Commission’s Farm to Fork Strategy still addresses food as a commodity instead of a human right or common good.

    • Peter Jackson
    • Marta Guadalupe Rivera Ferre
    • John Thøgersen
    Comment
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Research Highlights

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News & Views

  • Food contains thousands of different trace natural compounds, many of which remain largely unmeasured and undocumented. The network medicine approach sheds new light on how polyphenols, among the most important of these trace compounds, impact human health.

    • Dariush Mozaffarian
    News & Views
  • An assessment of global inequality in agriculture, food and health indicators between 1970–2010 reveals that significant progress has been made in some countries, but more is needed to achieve a truly equitable food system that delivers for the diets, nutrition and health of all people.

    • Shauna M. Downs
    • Elizabeth L. Fox
    News & Views
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