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Volume 2 Issue 2, February 2021

Parsing glioblastoma heterogeneity for redefined classification

Analysis of glioblastoma heterogeneity can classify the disease according to four fundamental functional properties, depicted here as branches of one tree. Genetic alterations common to these four subtypes are within the glioblastoma trunk, but each subtype diverges through distinct genetic lesions and gene-expression programs that incorporate prognostic and therapeutic attributes.

See Garofano et al. See also the articles by Richards et al. and Castellan et al., and the related News & Views by Hubert and Lathia

Image: Created by Anna Lasorella and Simona Migliozzi and inspired by work of Yiqi Li (Four season trees). Cover Design: Allen Beattie.


  • The election of Joe Biden to the US presidency has rekindled optimism in the world of science. To truly bring science to center stage will require bold political moves, the pulling together of all stakeholders, and time.



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Comment & Opinion

  • The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, poses a clear and present danger to the health and well-being of populations. Here we discuss its indirect impact on global cancer prevention and control efforts, particularly for cervical cancer. We suggest some comparisons between the COVID-19 pandemic and the human papillomavirus–induced cancer burden, as well as opportunities for translating pandemic-control strategies into effective cancer control.

    • Ophira Ginsburg
    • Partha Basu
    • Karen Canfell
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News & Views

  • The complexity of glioblastoma is becoming increasingly recognized. Three recent studies used single-cell approaches that integrate cellular states, transcriptional trajectories, and metabolic alterations to uncover multiple dimensions of cellular and molecular heterogeneity and provide a framework for additional functional investigation and therapeutic development.

    • Christopher G. Hubert
    • Justin D. Lathia
    News & Views
  • Metabolic reprogramming mediates resistance to therapy and rewires cancer-cell-signaling networks, paving the way to the discovery of enhanced treatment strategies through acquired vulnerabilities. A study now points to lipotoxicity dependent on Raf-1 kinase that occurs after activation of the liver receptor LXRα as a therapeutic intervention for the treatment of hepatocellular carcinoma.

    • Suchira Gallage
    • Jose Efren Barragan Avila
    • Mathias Heikenwalder
    News & Views
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