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GLIOBLASTOMA

Seeing the GBM diversity spectrum

Nature Cancer volume 2, pages 135–137 (2021)Cite this article

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The complexity of glioblastoma is becoming increasingly recognized. Three recent studies used single-cell approaches that integrate cellular states, transcriptional trajectories, and metabolic alterations to uncover multiple dimensions of cellular and molecular heterogeneity and provide a framework for additional functional investigation and therapeutic development.

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Fig. 1: Evolving views of the tumor-cell composition of GBM tumors.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

    Christopher G. Hubert

  2. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA

    Christopher G. Hubert & Justin D. Lathia

  3. Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA

    Christopher G. Hubert & Justin D. Lathia

  4. Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA

    Justin D. Lathia

  5. Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA

    Justin D. Lathia

Authors
  1. Christopher G. Hubert
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  2. Justin D. Lathia
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Correspondence to Justin D. Lathia.

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The authors declare no competing interests.

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Hubert, C.G., Lathia, J.D. Seeing the GBM diversity spectrum. Nat Cancer 2, 135–137 (2021). https://doi.org/10.1038/s43018-021-00176-x

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