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Ultrafast ultrasound microscopy of deep brain vessels
This issue highlights transcranial ultrafast ultrasound localization microscopy of brain vasculature, a portable magnetic resonance imaging (MRI) scanner for the head, a portable magnetic-resonance sensor for the grading of liver steatosis, iron-oxide-coated dextran nanoparticles for high-resolution MRI, contrast agents that use AND-gate logic to enhance fluorescence-guided imaging, a contrast agent for MRI that crosses the blood–brain barrier and that is sensitive to electric fields, and a Perspective on technology for 3D pathology.
The cover illustrates the imaging of vasculature deep in the human brain at microscopic resolution via ultrafast ultrasound localization microscopy of intravenously injected microbubbles.
To facilitate diagnostic radiology at the point of care, improvements in imaging hardware and processing software that raise the signal away from the noise floor are being leveraged toward improving device portability or accessibility.
Epileptic foci in mice can be better visualized with magnetic resonance imaging by using an intravenously administered nanoparticle that crosses the blood–brain barrier and is sensitive to the abnormal electrical activity of foci.
A prototype device for performing magnetic-resonance-imaging scans of the brain that integrates a lightweight permanent magnet and low-power gradient coils is suitable for eventual use at the bedside.
Ultrafast ultrasound localization microscopy of intravenously injected microbubbles enables transcranial imaging of deep vasculature in the adult human brain at microscopic resolution and the quantification of haemodynamic parameters.
A portable prototype scanner for brain MRI that uses a compact and lightweight permanent rare-earth magnet with a built-in readout field gradient generates clinically relevant images of the brain, as shown in adult volunteers.
A renally clearable nanoparticle consisting of a polysaccharide core and an amorphous-like iron oxide shell generates strong T1 MRI contrast, facilitating the imaging of microvessels, as shown in rodents and rabbits.
Optical contrast agents using AND-gate logic enhance the specificity and sensitivity of fluorescence-guided imaging in the resection of tumours and in the detection of metastases in mouse models of cancer.
An intravenously administered electric-field-sensitive contrast agent for magnetic resonance imaging that crosses the blood–brain barrier improves lesion visualization with high sensitivity and target-to-background ratio in mice.