Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
This issue highlights technology for interfacing neurons and nerves, including a nanoelectrode array for recording from thousands of connected neurons, reconfigurable nanophotonic probes for sub-millisecond deep-brain optical stimulation, an intraneural electrode array for the selective activation of optic-nerve fibres, a photovoltaic subretinal prosthesis implanted in non-human primates, and a small and ultrasonically powered implantable neural stimulator. The issue also highlights a device for the mechano-acoustic sensing of body motions, CAR-T-cell-functionalized nitinol thin films for the treatment of solid tumours and implantable functionalized carbon nanotube bundles as electrochemical sensors of disease biomarkers.
The cover illustrates a wireless device, designed to be conformally placed on the suprasternal notch, that provides continuous information of essential vital signs as well as talking time, swallow counts and sleep patterns.
The integration and miniaturization of components in electronic and photonic devices for interfacing with neural tissue allow for ever more precise neural recording and stimulation.
Wireless and leadless millimetre-scale implantable pulse generators, powered and controlled by ultrasonic links, enable the electrical stimulation of neural pathways in anaesthetized rats.
An array of 4,096 nanoelectrodes can record and stimulate intracellular action potentials, as well as excitatory and inhibitory post-synaptic potentials, from thousands of connected mammalian neurons in culture.
A wireless device designed to be conformally placed on the suprasternal notch can continuously provide real-time information of essential vital signs as well as talking time, swallow counts and sleep patterns.
Functionalized multi-walled carbon nanotubes twisted into helical fibre bundles that mimic the hierarchical structure of muscle can be used for the long-term monitoring of multiple disease biomarkers in vivo.
A near-infrared-light-sensitive photovoltaic subretinal prosthesis triggers behavioural responses in awake macaques, even two years after device implantation.
Micropatterned nitinol (a nickel titanium alloy) thin films loaded with human CAR-T cells and implanted into tumours foster the expansion of the cells and extend animal survival in mouse models of human tumours.
A wireless and battery-free 1.7-mm3 neural stimulator implanted onto the sciatic nerve of rats allows for repeatable stimulation across a range of physiological responses.
A reconfigurable nanophotonic silicon probe, implanted in anaesthetized mice, that switches multiple optical beams in less than 20 μs enables the optical stimulation of multineuron spike patterns in the brain at sub-millisecond precision.
An electronic interface with 4,096 electrodes can intracellularly record postsynaptic potentials and action potentials from thousands of connected mammalian neurons in vitro.