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Volume 4 Issue 1, 1 January 2020

Therapeutic extracellular vesicles produced at scale

This issue highlights the use of deep learning to detect anaemia from retinal fundus images, the local delivery of newly identified vasodilators for reducing ureteral contractions, a biomaterial-based vaccine to treat acute myeloid leukaemia, the reduction of the therapeutic dose of silencing RNA via its integration into extracellular vesicles, cellular nanoporation for the large-scale production of functional mRNA-encapsulating exosomes, anionic nanoparticles that enhance the intestinal permeability of orally delivered proteins, base editing in a mouse model of tyrosinemia, the optimization of the delivery of base editors, and a comparison of compatibilities in protospacer adjacent motifs and of on-target and off-target activities of SpCas9 variants.

The cover illustrates the production, via cellular nanoporation, of large quantities of extracellular vesicles loaded with endogenously transcribed therapeutic mRNAs and targeting peptides.

See Yang, Z. et al.

Image: Ella Marushchenko. Cover design: Alex Wing.

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