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Volume 3 Issue 8, August 2019

A sprayed supramolecular film cuts down on pericardial adhesions

This issue highlights a thermogelling polymer endotamponade for retinal-detachment repair, a supramolecular gel as a post-operative pericardial adhesion barrier, a mechanical injector that targets tissue by sensing the loss-of-resistance on encountering softer tissue or a cavity, a viscoelastic adhesive epicardial patch for treating myocardial infarction, bioresorbable photonic devices for the spectroscopic characterization of tissues and biofluids, and wireless soft optofluidic probes with plug-like drug cartridges for chronic in vivo pharmacology and optogenetics.

The cover illustrates a sprayable supramolecular hydrogel that adheres to the pericardium to reduce the incidence and severity of post-surgical adhesions. The image is a composite of two photographs, one from a gel-coated sheep heart (left) and one from an uncoated sheep heart (right).

See Stapleton et al.

Image: Athena Chien, Stanford University. Cover design: Alex Wing

Volume 3 Issue 8

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  • Soft biomaterials for implantation in the body are increasingly designed to be functional for a finite time and to then disappear via degradation or resorption.

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  • A rapidly gelling, biocompatible co-polymer, tested in rabbit and non-human-primate models of retinal detachment, makes for an effective replacement of the damaged vitreous.

    • Stanley Chang
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  • A viscoelastic adhesive cardiac patch with optimal mechanical behaviour, determined using a computational model, restores heart function and slows down pathological remodelling following myocardial infarction in rodents.

    • Dawn Bannerman
    • Simon Pascual-Gil
    • Milica Radisic
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  • Smartphone-controlled optofluidic neural implants with replaceable and replenishable plug-like drug cartridges enable the selective wireless manipulation of brain circuits in rodents via chronic pharmacology and photostimulation.

    • John F. Zimmerman
    • Bozhi Tian
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