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The efficacy of adoptive cell therapy for pancreatic cancer can be augmented by antigen-specific cytotoxic T cells genetically engineered to overexpress a C-X-C chemokine receptor whose ligand is highly expressed by pancreatic cancer cells.
Deep surgical wounds can be monitored via conductive multifilament surgical sutures incorporating ‘sensing pledgets’ bearing capacitive sensors operated via harmonic radiofrequency identification.
A microwell chip facilitates the differentiation of aggregates of human induced pluripotent stem cells into pancreatic-duct-like organoids and the characterization of the differentiation process at the single-cell level.
The elastic modulus of the superficial and deep layers of the skin can be dynamically measured via wearable conformal electromagnetic devices consisting of a vibratory actuator and a soft strain-sensing sheet.
Organic electrochemical transistors functionalized with antigen-specific nanobodies can rapidly and specifically detect antigens at attomolar-to-nanomolar levels in bodily fluids.
An efficient protocol for the preparation of DNA libraries for the analysis of methylation patterns in cell-free DNA in plasma enhances the sensitivity of bisulfite sequencing for the early detection of lung cancer.
In tendon cells under shear stress, the induction of an influx of calcium by the mechanosensitive ion channel PIEZO1 upregulates collagen crosslinking, which increases tendon stiffness and potentially improves jumping performance.
The restoration of a local chemokine gradient by nanoparticles non-covalently anchored on the surface of systemically administered red blood cells delays cancer progression in mouse models of lung metastasis.
An analysis of the neural coding of speech sounds in anaesthetized gerbils shows that sound-processing algorithms used by hearing aids can degrade the wearer’s ability to discriminate sounds.
The dynamics of multiregional brain networks in response to temporally varying patterns of ongoing direct electrical stimulation can be predicted by modelling, with variabilities in prediction accuracy explained by at-rest functional connectivity.
The time course of tumour responses to immunotherapies can be mathematically predicted on the basis of tumour-growth rates, the rates of immune activation and of tumour–immune-cell interactions, and the efficacy of immune-mediated tumour killing.
A prototype device for performing magnetic-resonance-imaging scans of the brain that integrates a lightweight permanent magnet and low-power gradient coils is suitable for eventual use at the bedside.
Epileptic foci in mice can be better visualized with magnetic resonance imaging by using an intravenously administered nanoparticle that crosses the blood–brain barrier and is sensitive to the abnormal electrical activity of foci.
The sustained expression of RNA-targeting Cas9 delivered intramuscularly or systemically by adeno-associated viral vectors eliminates pathogenic foci of expanded-repeat transcripts and reverses muscle-disease phenotypes in mouse models of myotonic dystrophy type 1.
Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration.
By using CRISPR and transposon constructs, pigs have been genetically modified to inactivate endogenous retroviruses and to enhance the compatibility of their organs with the human immune and coagulation systems.
The DNA methylation of the promoter region of the oncogenic Yes-associated protein is reversibly regulated by the stiffness of the extracellular matrix.
