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Senolytic compounds have shown promise for the treatment of aging-related diseases in animal models. Here, to discover new small molecule senolytics, Wong, Omori and colleagues introduce a graph neural network platform, identify structurally diverse compounds with favorable drug-like properties and confirm one compound’s in vivo activity in aged mice.
Shi, Liu, Gao et al. present a strategy to monitor and selectively eliminate senescent cells in mice during aging through controllable photodynamic therapy, which inhibited the age-related functional decline.
