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Epigenetic clocks emerged as crucial biomarkers of the aging process, but their use has so far been limited to bulk samples. Trapp et al. unveil a new statistical framework that enables epigenetic age profiling at single-cell resolution.
Wang et al. report a mouse model for targeting of cells with high p21 expression. Using this model, they are able to monitor, sort, image, eliminate or modulate these cells in vivo, which could be a valuable tool to study senescent cells.
