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NB: AS OF JANUARY 1, 2023 THIS JOURNAL IS PUBLISHED WITH ELSEVIER: https://www.sciencedirect.com/journal/mucosal-immunology

Volume 14 Issue 2, March 2021

This cover image depicts in situ proximal ligation assay (PLA) using antibodies against CD47 and CD11b on non-permeabilized murine bone marrow-derived neutrophils. Nuclei were counterstained with Hoescht 33342 (blue). This micrograph demonstrates CD47 and CD11b are in close proximity (within 40 nm) and presumably physically associated on the plasma membrane of neutrophils (white dots). Image courtesy of Veronica Azcutia and colleagues, University of Michigan School of Medicine. For further information, please see article in this issue, page 331.

Volume 14 Issue 2

Comment

  • Type 1 Innate lymphoid cells (ILC1) accumulate in the inflamed mucosa of patients with Crohn’s disease (CD) but their role in CD pathogenesis remains poorly known. In a recent issue of Nature materials, Jowett et al. (Nat. Mat. 2020) used a coculture model with intestinal organoids to show that ILC1 could promote intestinal epithelial growth and tissue remodeling through an unexpected mechanism that involves the transforming growth factor 1 (TGF-β1) and the metalloproteinase MMP9.

    • Fatima Hariss
    • Bertrand Meresse
    Comment

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