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Volume 50 Issue 4, April 2021

Ischemic stroke in the brainstem

Strokes that occur in the human brainstem are often lethal; if patients do survive, they are usually left with severe cognitive and/or motor disabilities. Animal models are critical to understanding and treating stroke, but targeting different areas of the brain, such as the brainstem, can be difficult. A new Protocol this month details the steps to induce a focal infarction in the rat brainstem.

See Namioka et al.

Image: Marina Spence. COVER DESIGN: Marina Spence

Volume 50 Issue 4

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In This Issue

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News Feature

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Technology Feature

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Research Highlights

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News & Views

  • A new CRISPR/Cas9 method that can generate F0 mutant zebrafish has the potential to cut costs, spare time, and reduce animal use for researchers interested in screening loss-of-function alleles in vivo.

    • Wouter Masselink
    News & Views
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Protocol

  • A new rat model of brainstem ischemia is described. Selective ligation of four points of the lower basilar artery causes a localized brainstem ischemic lesion in adult rats, resulting in hemiparesis, as well as abnormal posture, body balance and locomotion.

    • Ai Namioka
    • Takahiro Namioka
    • Osamu Honmou
    Protocol
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