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Our study showed that overweight and obesity were associated with a higher prevalence of masked uncontrolled hypertension but not masked hypertension, indicating that clinic blood pressure might overestimate antihypertensive treatment effects in patients with overweight and obesity.
We demonstrated a key role of estrogen in the sex difference of maternal HFD-induced programming of vascular dysfunction and development of hypertensive phenotype in adulthood by differently regulating of vascular AT1R and AT2R gene expression through DNA methylation mechanism.
The permanent inhabitants exposure to the hypoxia environment long-termly, it may impose negative impact on hypertension. There were 32 studies (86,487 participants) were included for this study review and analyses. We found a curvilinear association between altitude and prevalence of hypertension with peak about 3300 m.
Long-term variability of systolic blood pressure indicated by root mean square error is significantly associated with a higher risk of type 2 diabetes mellitus in middle-aged Japanese.
A unique metabolomics signature is evident with masked hypertension, with possible differences in the stages of branched chain amino acid metabolism early and later in life.
Note:rs3847987 is single nucleotide polymorphism of vitamin D metabolic pathway gene VDR. According to the principle of Mendelian Randomization study, if rs3847987 was associated with vitamin D deficiency as well as hypertention, and the association between vitamin D deficiency and hypertention was observed. Then, it could be come to the conclusion that vitamin D deficiency may be a causal factor of hypertention.
This retrospective cohort study using Japanese claims data included 13797 pregnant women with hypertension. The study period was divided into three terms to evaluate the influence of regulatory actions. Significant changes were identified in the trend of prescription proportions of nifedipine and hydralazine, but not in pregnancy outcomes.