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    Currently, there are more than 58 antibodies clinically available for the treatment of various diseases including cancer, chronic inflammation, and infection. In 2016, eight antibodies were newly approved, and the annual number of antibodies approved has been increasing for the past decade. This special feature of Experimental & Molecular Medicine presents reviews and original articles focusing on therapeutic antibodies and biopharmaceuticals.

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    Obesity is a major risk factor for various metabolic diseases including type 2 diabetes, hyperlipidemia, cardiovascular diseases and certain types of cancer. Over the last several decades, mounting evidence suggests the importance of inter-organ metabolic communication and genetic and environmental factors on the progress of obesity as well as its associated metabolic syndrome. In this special issue, 6 review articles deal with recent findings on the crosstalk between metabolic organs in the regulation of energy homeostasis and the etiology of obesity. Also, recent advances in genetic and epigenetic mechanism involved in the molecular pathophysiology of metabolic disease are discussed.

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    It has been 50 years since Michael Anthony Epstein and Yvonne Barr discovered Epstein-Barr Virus (EBV) particles in cell lines cultured from tumor tissue from a Burkitt lymphoma. Since the initial discovery of the virus, more than 20,000 scientific papers on the characteristics, functions and oncogenic mechanisms of viral genes, the spectrum of EBV-associated diseases, and treatment of patients have been published. Experimental & Molecular Medicine contains six review articles that provide an overview of our current understanding of Epstein-Barr virology and oncogenesis and of EBV-associated neoplasm.

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    Studies of neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD) and Amyotrophic Lateral Sclerosis (ALS) are becoming increasingly important in this rapidly growing population of ageing. This special issue, titled “Neurodegenerative diseases and their therapeutic approaches”, discusses the underlying pathogenic mechanisms and therapeutic implications for AD and other age-associated neurodegenerative disorders, with 5 specially-invited review articles. Each review provides readers an current overview of the researches and deep insights and perspectives on future studies on AD and related neurodegenerative disorders.

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    Effective vaccines that protect at mucosal surfaces are much needed. This special feature of Experimental & Molecular Medicine contains four review articles that provide an overview of our current understanding of mucosal immunity and mucosal vaccines. The articles cover a range of key topics including regulatory T cell vaccination, antigen targeting to M cells, mucosal mast cells and the role mucosal dendritic cells play in shaping mucosal immunity.

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    Throughout the year, Experimental & Molecular Medicine (EMM) highlights research into the clinical benefits for human health from experimental and translational research performed using specific molecular tools. In November 2013, EMM offers a series of reviews covering the state-of-the art in representative areas in stem cell research and, in addition, original research covering selected areas of stem cell biology and therapeutic applications.