Special Feature on molecular pathophysiology of obesity and metabolic diseases: crosstalk between metabolic organs
Obesity is a major risk factor for various metabolic diseases including type 2 diabetes, hyperlipidemia, cardiovascular diseases and certain types of cancer. Over the last several decades, mounting evidence suggests the importance of inter-organ metabolic communication and genetic and environmental factors on the progress of obesity as well as its associated metabolic syndrome. In this special issue, 6 review articles deal with recent findings on the crosstalk between metabolic organs in the regulation of energy homeostasis and the etiology of obesity. Also, recent advances in genetic and epigenetic mechanism involved in the molecular pathophysiology of metabolic disease are discussed.
