Abstract
Sleep enhances plasticity in neocortex, and thereby improves sensory learning1. Here we show that sleep itself undergoes changes as a consequence of waking experience during a late critical period in cats and mice. Dark-rearing produced a robust and reversible decrement of slow-wave electrical activity during sleep that was restricted to visual cortex and impaired by gene-targeted reduction of NMDA receptor function.
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Acknowledgements
We thank H. Mori and M. Mishina (Univ. Tokyo) for kindly providing NR2A KO mice, S. Fujishima for animal care, and M. Fagiolini for inspirational comments.
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Miyamoto, H., Katagiri, H. & Hensch, T. Experience-dependent slow-wave sleep development. Nat Neurosci 6, 553–554 (2003). https://doi.org/10.1038/nn1064
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DOI: https://doi.org/10.1038/nn1064
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