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This manuscript investigates the binding mode of a potent SARS-CoV-2 neutralizing antibody. N3-1 is escaped by Omicron variants due to altered spike dynamics. This work suggests the need for innovative vaccine designs to combat evolving variants.
This study reveals that ATG7, beyond its established role in autophagy, interacts with PDCD4 and AKT1 to regulate translation during metabolic stress. The ATG7PDCD4 axis operates as a metabolic adaptation pathway, conserving energy and fostering cell survival under stress.
The progranulin-derived synthetic protein Atsttrin affects osteoclastogenesis and osteoblastogenesis via the TNFR signaling pathway, suggesting that this protein could potentially be used to treat inflammation-related bone diseases like osteoporosis.
A genome-wide study suggests that the response of the pituitary gland to thyroid hormone is regulated by receptor-enhancer complexes that adjust dynamically to hypothyroid and hyperthyroid conditions.
An insect assemblage gathered from the Chorrillo Formation in Argentina constitutes an important set of insect body fossils for the Maastrichtian interval in the Southern Hemisphere.
Comprehensive characterization of the glucose-6-phosphate dehydrogenase (G6PD) Meyer variant that contains an R219G substitution suggests compromised dimerization, stability, and catalytic activity of the mutant enzyme causes chronic hemolysis.
A scRNA-seq study reveals the dynamic landscape of the intestinal cellular microenvironment during radiation-induced intestine injury and regeneration.
A combination of slice physiology, in vivo optogenetics, and behavioral analyses shows that the cortical-cortical connection between bilateral anterior cingulate cortex facilitates pain perception and enhanced anxiety-like behaviors associated with acute and chronic pain in adult mice.
Long-read sequencing of fish and plant samples demonstrate that ethanol suitably preserves field-collected specimens for genome assembly of organisms, reducing the necessity for cryogenic storage.
An integrated approach using phylogeographic data, climate modelling, and network analysis unlocks insights into the post-glacial expansion of the sand fly Phlebotomus mascittii in Europe and suggests two potential (parallel) dispersal routes.
An MEG study on semantic processing of concepts in a silent picture naming task indicates that the brain gradually accumulates information before reaching a plateau.
Skeletal muscle aging is characterized by the loss of muscle mass and function, mainly attributed to the atrophy of glycolytic fibers. The underlying mechanisms driving this impairment were investigated in unbiased approaches in a glycolytic muscle.
This work discovers that transcranial photobiomodulation enhances lymphatic clearance of inflammatory factors from the brain of diabetic mice, providing the reverse of microglial dysfunction and amelioration of physiological disorders.
Protein crotonylation, as one of post-translational modifications (PTMs), can be further modified, herein named post-PTM (PPM) by a monooxygenase in Streptomyces to regulate substrate protein turnover and cell physiology.
The MetaInvert database provides draft genome assemblies for 232 soil invertebrate species, representing 14 common groups and 94 families, that will aid in the discovery and management of soil biodiversity.
The fibroproliferative properties of keloids are regulated by the HEDGEHOG-GLI1 signaling pathway, and inhibition of this pathway reduced the number of keloid stem-like cells, expression of keloid-specific genes, and the keloid fibrosis phenotype.
A multi-parameter real time tracking setup that synchronizes intestinal circular and longitudinal muscle contractions, intraluminal pressure, and volume recordings to decipher the parameters influencing peristalsis and luminal discharge in mice.
Development of a CRISPRi gene modulation platform to target key cardiac ion channels in human iPSC-CMs offers correlation of function measured by all-optical electrophysiology and molecular underpinnings.
Double-stranded RNA acts both preventatively and curatively against myrtle rust disease in perennial plants. Spray treatment reduces disease coverage and improves long-term plant health, offering a solution to long-standing myrtle rust epidemics.
A chromosome-level genome for the Silkie chicken (Gallus gallus domesticus) provides insight into both the basis of fibromelanosis in these animals and, more broadly, unresolved genes in genome assemblies for related chicken subspecies.