Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
In aggressive bladder cancer cells, the transcription factor EB is activated, leading to increased endosomal phosphatidylinositol-3-phosphate levels and lysosome dispersion to the cells’ periphery.
The study of the role of circRNA432 in a sea cucumber expands our knowledge about the relationship between circRNA and miRNA in marine invertebrates and highlights the functional links between the non-coding RNA and the pathogen-induced phagocytosis.
Connectome harmonic decomposition analysis reveals how neuromodulation and the network architecture of the human connectome jointly shape consciousness and distributed functional activation across scales.
An analysis of eye movements and EEG activity during a smooth pursuit eye movement task suggests that the process of reliability-based optimal information integration occurs in sensorimotor behaviors.
A HEK293 cell line lacking all Gαi subunits is generated which enables the measurement of coupling between a GPCR and individual Gαi subunits upon transient re-expression of a specific Gαi subunit.
FRET and confocal patch-clamp fluorometry in oocytes is used to analyze glutamateinduced conformational changes and dimerization of mGluR 1-8 homo- and heterodimers.
The analysis of fetal MRI data and follow-up language assessments reveal that temporal sulcus depth asymmetry is a potential biomarker for maturity and integrity of neural correlates of language.
A circuit running from CamKIIα-positive neurons of the medial preoptic area to the ventral periaqueductal gray induces exploration of a fear-conditioned place and facilitates fear extinction in mice.
A hepatic lncRNA Gm19619, which is repressed by vertical sleeve gastrectomy but upregulated by obesity and fasting, regulates gluconeogenesis and lipid metabolism in mice through Foxo1-G6pc/Pck1 and Lepr signaling pathway respectively.
Using single nuclei and single cell RNA-seq, 3 FAP cell subpopulations are identified in human skeletal muscle, with an MME+ subset showing increased adipogenic potential under fatty infiltration conditions.
The mechanism of methylmannose polysaccharide (MMP) biogenesis in nontuberculous mycobacteria (NTM) is characterized, which involves an MMP-specific hydrolase (MmpH) and a rare mannosyltransferase (ManT). MmpH and ManT structures are presented.
miRNA-125b, a translational repressor of p53, undergoes initial HuR-mediated exosomal export in response to DNA damage, leading to p53 upregulation, which in turn induces transcription and processing of miR-125b causing inhibition of p53 expression.
An analysis of phasing and imputation performances using iPSYCH consortium data across multiple methods and data integration protocols provides a useful framework in designing workflows to construct next-generation biobanks or conduct biobank-scale analyses.
The clinical HDAC inhibitor zabadinostat increases MHC class I and II expression in dendritic cells, activates T and B cells, and enhances adaptive immune responses to COVID-19 spike protein in mice.
The longitudinal SARS-CoV-2-specific antibody response in human milk of lactating women receiving an mRNA-based booster vaccine indicates that both homologous and heterologous boosters enhance SARS-CoV-2-specific antibodies in human milk.
Functional MRI data from Chinese-English bilingual participants during a reading task reveals linguistic feature-specific accommodation and assimilation between first and second languages.
The antidiabetic drug, metformin, helps E. coli gather vitamin B12 from the environment by increasing the expressions of transporter genes in a RcdA-dependent manner.
Single-cell and bulk transcriptomic analyses between dissected components of the pig and human colonic enteric nervous system provide insight into the relevance of pig models for understanding human colonic function and neuromodulation.