Review Articles

Neurofibromin’s signaling pathways, post-translational modifications and key residues are explored to better understand its function and potential therapeutic targets.

The role of mesenchymal stem cells (MSC) in axial spondyloarthritis is reviewed, with a focus on the potential therapeutic strategies employing both MSC and MSC extracellular vesicles.

This review highlights the biomechanical, biophysical, and biochemical modulators of cytoskeletal remodeling during tissue neogenesis in early development and postnatal healing for targeted tissue regeneration and regenerative medicine applications.

This state-of-the-art Review highlights the evolution of neuromodulation and neuroprosthetic systems from sensorimotor to cognitive disorders.

A detailed Review across animal and human societies provides insight on the causes and consequences of adult sex ratio skew.

Myanmar amber collection and study in palaeontology is clouded with ethical and legal issues. Here, the history and legality of Myanmar amber use in the literature is reviewed.

A review of the function of the Dystrophic Glycoprotein Complex (DGC) in mechanosignaling provides an overview of the various components of DGC and potential mechanopathogenic mechanisms, particularly as they relate to muscular dystrophy.

This review discusses the recent advances in the engineering of bioartificial muscle. The applications highlighted include cultured meat, biorobotics, and muscle implants.

This review discusses emerging roles for the NLR family pyrin domain containing 6 receptor (NLRP6) in intestinal homeostasis, inflammation, cancer, the nervous system and liver disease.

In this review, numerous aspects of sand flies as vectors of Leishmania parasites—from biology to the vector parasite interactions—are discussed.

Walker et al. review methods used to analyse spatial transcriptomics data and discuss open questions and areas of future development.

Evanthia Pangou and co-authors review recent insights into the important roles of non-proteolytic ubiquitylation in cellular signaling as well as in physiology and disease.

Kozlowski, Crook, and Ku review current state-of-the-art techniques in culturing and manipulating organoids without the use of EHS-tumor-derived matrix, the most popular of which is Matrigel by Corning. They cover organoid-based applications of different matrix types, ranging from natural sources (decellularized ECM, purified ECM proteins, polysaccharides), synthetic sources (e.g. PEG-based), and recombinant peptide-based systems.

Zhang et al. describe metrics for evaluating glycaemic variability (GV) in clinical practice and summarize the role and related mechanisms of GV in diabetic neuropathy, including cardiovascular autonomic neuropathy, diabetic peripheral neuropathy and cognitive impairment. They aim to stimulate ideas for the treatment of diabetic neuropathy.

Garbarino et al review recent experimental and epidemiological developments regarding immune responses to sleep deprivation and consider the role for the sleep deprivation induced immune changes in increasing the risk for chronic diseases.

In this Review, Bhat et al. highlight ways to mine crop haplotypes and apply them for dissecting complex traits and genomics-assisted breeding (GAB) approaches. This Review presents new avenues to discover superior haplotypes and assemble them in targeted manner in crop breeding for faster delivery of high-yielding cultivars with better adaptation to future climates.

Melo, Maasch and de la Fuente-Nunez review the current practices in use of artificial intelligence in the discovery of antibiotics and antimicrobials. They also provide details about the best-practices that should be engaged with during computational drug discovery, including open science and reproducibility.

In this review Widden and Placzek synthesize studies characterizing the influence that myeloid cell leukemia-1 (MCL1) has on cell proliferation, DNA damage response, autophagy, calcium handling, and mitochondrial quality control to highlight the broader scope that it plays in cellular homeostasis regulation. They discuss which pathways are likely to be impacted by emerging MCL1 inhibitors, as well as highlight non-cancerous disease states that could deploy BH3-mimetics in the future.

In this Review, Laura Martinez-Vidal et al. summarize current knowledge of factors affecting extracellular matrix (ECM) remodeling in the context of pathological mechanical changes to tissue properties. They focus on the importance of research on tissue stiffness to the development of diagnostic tools and therapies to treat urological disease.

Gómez-López and co-authors discuss advances in the development of in vitro and in vivo models for lung squamous cell carcinoma (LUSC) and their role in understanding the cellular and molecular processes driving LUSC development and responses to therapy.