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This study presents in vitro, in vivo, and human genetic evidence showing that the chromatin regulator SmarcAL1 plays an indispensable role in regulating cellular lipid metabolism, a mechanism linked to the lipid phenotypes seen in SIOD patients.
A set of functional genomics and statistical analyses identifies and establishes key determinants of transcriptional state dynamics and plasticity during tumor growth and under treatment in urothelial bladder carcinoma.
The heterogeneous structural ensemble of the constitutively active SHP2E76K mutant has been determined by means molecular dynamics simulations in agreement with experimental data from small-angle X-ray scattering.
An optimized zebrafish gene-tagging strategy was developed to enable easy and high-efficiency knock-in (KI), high odds to obtain seamless KI germlines, and sensitive in vivo tracing of proteins with different abundance.
Breast cancer resistance and relapse may stem from polyploid giant cancer cells (PGCCs), and eradicating them poses a challenge. A precise, high-throughput single-cell analysis can identify compounds that target non-PGCCs, PGCCs, or both cell types.
Natural Killer (NK) cells play a role in suppressing the development of certain subtypes of acute myeloid leukemia as shown by employing Rag2−/− mice as model system, which lack functional lymphocytes but have hyperactive NK cells.
A new model proposes that the motor system updates motor commands by processing visual feedback with a divisive normalization, which provides a mechanistic explanation for visuomotor learning impairment with the level of visual feedback uncertainty.
Environmental microbes enhance Drosophila oogenesis by increasing the number of germline stem cells, suppressing apoptosis and accelerating ovarian cell division through hormonal pathways.
Like classical psychedelics, nitrous oxide reduces functional differentiation in human frontoparietal and somatomotor networks, flattening functional brain geometry and disrupting temporal dynamics in association with the psychedelic experience.
A study on rats shows how to modulate memories by associating their recall with non-invasive behavioral experiences: timing defines the nature of change acting on the key mechanisms of the behavioral tagging process underlying memory reconsolidation.
Environmental bacteria contain antibiotic-resistance genes, which worsens the antibiotic resistance crisis. This study helps understanding the sequence-structure-function relationships of the phosphotransferases that confer capreomycin resistance.
Neurobiological analysis of the fish parasite, Cryptocotyle lingua, shows streamlined signaling and the absence of key pathways, including nitric oxide synthase, and sheds light on trematode host-infection adaptations.
Structural and biochemical studies of Met18, a CIA Pathway heat repeat protein, show that Met18 forms different oligomers, has a flexible N-terminus that binds client protein Leu1, and a C-terminus that binds CIA protein Cia2.
A study uses MEA analysis, computation, and simulations to demonstrate how BDNF treatment after excitotoxic injury remodels hippocampal networks by promoting inhibitory neuron survival while indirectly strengthening weak excitatory synapses.
A structural and functional characterization of salivary acid phosphatase-like proteins derived from the flea Xenopsylla cheopis demonstrating their ability to bind host biogenic amines and leukotrienes, potentially favouring blood acquisition.
A pan-cancer study indicates two mesenchymal-like tumor subtypes with distinct intrinsic or extrinsic driving mechanisms and could be used to guide chemotherapy and immune therapy.
Arsenic and ultraviolet radiation (UVR) are potent carcinogens. This study shows that a co-exposure to both arsenic and UVR leads to an accelerated mouse skin carcinogenesis due to an enhanced accumulation of UVR-associated somatic mutations.
Structural and biophysical characterization of a small molecule binding to Cbl-b E3 ligase reveals an intramolecular glue mechanism locking the protein in an inactive state.
A combination of quantitative proteomics and functional analyses in a T-cell line unveils a role for the centriolar satellite component CEP131 in the maintenance of proteostasis and the fine-tuning of mitochondrial apoptosis.
In Drosophila melanogaster, the red-shifted bioluminescence system Akaluc/AkaLumine is useful for studying gene expression, cell numbers, and innate immunity levels in deep tissues without harming the individual.