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Site saturation study of BlaC β-lactamase reveals that high fitness of clavulanic acid resistant double mutants is a result of positive epistasis and strong synergistic effects between chosen functional residues.
Development of phenol-tolerant E. coli strains via adaptive evolution provides insight into the molecular mechanism of phenol toxicity and highlights the potential of phloroglucinol-induced ferroptosis-like cell death in cancer biology.
Short-term repeated SARS-CoV-2 passaging in immune-naïve mice leads to the virus acquiring lineage-specific differences in antibody resistance, interferon suppression and infection phenotypes.
A priority index solution to critical Covid-19 comprises both the target index and the drug index, serving as dual indexes to accelerate translational medicine for host genetics.
A Nutritional Geometry study in mice identifies complex gene regulatory responses to differences in dietary macronutrient contribution including differential splicing of thousands of genes, most of which did not undergo gene expression changes.
A retinoic acid analogue, TTNPB, improves clonal expansion in adherent and suspension culture of hPSCs by promoting cellular adhesion and self-renewal through the upregulation of Claudin 2 and HoxA1.
Priming macrophages with A. muciniphila enhances intracellular survival and diminishes pro- and anti-inflammatory signals. Transcriptional analysis of macrophages shows upregulation of genes related to phagocytic capacity and metabolic adjustments.
Auditory stimulation during REM sleep in a cohort of healthy adults can modulate REM time and subsequently influence the participants’ performance in memory-related tasks.
A Ketogenic Diet (KD) that improves memory in aged C57BL/6 mice is tested in APP/PS1 Alzheimer’s mice. Seven months KD rescues Long-Term-Potentiation to wild-type levels, as does a one-hour soak with 3 mM Betahydroxybutyrate. KD increases synaptic pathways but does not alter Aβ amyloid.
This study explores the synergistic effects of photothermal therapy and silencing Gal-9 to achieve photothermal immunotherapy treating melanoma with an integrated FSGG nanostructure.
Bob1 manages ICOS and cellular respiration in Tfh cells, ensuring the sustained generation of specific humoral responses. This likely contributes to persistent inflammation resulting from recurring allergen exposure.
The Drosophila ubiquitin ligase detour and its mammalian homologs ZNRF1/2 are modulators of autophagy that interact with subunits of the HOPS complex and are required for healthy aging.
Transcriptomic analysis of the airway epithelia in asthma patients identifies several neutrophilic signatures and targets associated with asthma severity, and highlights the potential therapeutic value of Reperixin in managing deteriorating asthma.
Combining polygenic risk scores for both disease-related risk factors and disease risk factors using data from the UK Biobank can improve prediction efforts across distinct human diseases.
FMRI and behavioral experiments on humans suggest that the early visual cortex makes a limited contribution to spatial extent perception, implying the need for a downstream mechanism to transform its topographic anisotropy to match perception.
A mesocosm heating experiment reveals that corals stressed by bleaching and/or heating exude compositionally distinct dissolved organic matter, which in turn yields elevated microbial loads and may increase abundance of copiotrophic and putatively pathogenic bacterioplankton on stressed coral reefs.
Tir, a bacterial effector, exploits host-like disorder to rewire cellular processes via dimerization, lipid binding, and phosphorylation, revealing a versatile intracellular strategy for infection.
Mouse genetics indicates that serine hydroxymethyltransferase 2 maintains hepatic methylation potential and plays stage-specific roles in the pathogenesis of non-alcoholic fatty liver disease.
Systematic culture and genome sequencing of thoracic airway commensal bacteria finds many potential influences on lung health and disease. Polyomics of differentiated airway epithelium also suggest pathways that may sustain host-microbial interactions.