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UFObow is a single-wavelength excitable Brainbow technique, incorporating three newly developed blue-excitable fluorescent proteins. This method facilitates mapping of immune cells’ spatial distribution at a single-cell resolution.
In this study, the authors show that lysine acetyltransferase 5 inhibits NLRP3-mediated cardiomyocyte pyroptosis via STUB1, relieving myocardial ischemia-reperfusion injury.
A study on plant community structure suggests that the underlying mechanisms that dominate vertical structural complexity variation will gradually shift from resource acquisition strategies to conservation priority strategies as climates shift from favorable to extreme.
Documentation of women’s inclusion in Indian academia and conferences by BiasWatchIndia reveals the scale of underrepresentation of women across science, technology, engineering and mathematics.
An in vivo study demonstrates that circEYA3 plays an important role in exacerbating the progression of intervertebral disc degeneration by modulating the NF-κB signalling pathway through regulation of the miR196a-5p/EBF1 axis.
HtrA2, a mitochondrial protease that is associated with Parkinson’s disease, is playing an important role in the cleavage of DELE1 and the activation of HRI-directed integrated stress response during mitochondrial protein import stress.
Using a humanized mouse model, this study demonstrated that HIV-1 infection in mice impaired extinction of cocaine seeking, altered glial response in corticolimbic structures, and dysregulated the peripheral immune system.
Procrustes is a machine-learning algorithm that can overcome batch effects across RNA-seq data obtained by different sample preparation methods, like exome capture-based or poly-A RNA-seq protocols.
A study on the small model fish medaka suggests the existence of an intra-pituitary pathway involved in seasonal regulation of gonadotrope proliferation and hormone synthesis in vertebrates via pituitary thyrotropes and folliculostellate cells.
Shox2 acts as a safeguard but not determinant for cardiac pacemaking cell fate via the Shox2-Nkx2-5 antagonistic mechanism, which is segregated from its morphogenetic regulatory role in sinoatrial node development.
Regulatory genetic variants repertoire in pig liver was expanded using RNA-seq, H3K27ac ChIP-seq, and DNA sequencing. These genetic foundations facilitate the dissection of molecular mechanisms underlying complex traits.
This study shows that NETosis is an auto-amplified process whereby NETotic neutrophils can induce secondary NETosis in proximal naïve neutrophils, resulting in spatial propagation of NETs.
A review summarizes how ATG7 is precisely programmed by genetic, transcriptional, and epigenetic modifications in cells and its functions, including the relationship between ATG7 and aging-related diseases.
The biochemical characterisation of S-adenosyl-l-homocysteine hydrolases from all three domains of life supports the assumption that alternative routes for methyl metabolism coupled to purine salvage exist in some classes of Euryarchaeota.
Use of a robotic balance simulator demonstrates that humans can learn to balance with long sensorimotor delays in different contexts (movement direction, muscle effectors) and generalize learned control to untrained contexts.
Clonality study in HCC finds diverse evolution patterns. Linear HCC is less aggressive, with GTF2IRD2B driver mutations. Non-linear has shallow/deep branching patterns with frequent TP53 driver mutations.
Using patient-derived induced pluripotent stem cells, the authors show that the transcription factor GFI1B and the lysine demethylase KDM1A/LSD1 promote gene programs while repressing those involved in myeloid differentiation.
The methyltransferase TrSAM from Trichoderma reesei is suggested to have an important role in regulating the expression of cellulase and heterologous proteins initiated by cbh1 promotor through interacting with ACE1R383.
A Perspective on how the tools of behavioral science and the emerging field of diverse intelligence help to understand decision-making of cellular collectives in evolutionary and biomedical contexts.