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A genome-wide association study of 57 trace elements measured in up to 6564 Scandinavians, identifies genetic loci associated with blood levels of essential and non-essential trace elements and explores their effects on health outcomes.
A functional genomics approach in patient derived cell lines of Favorable Histology Wilms Tumor identifies suppression of TRIP13 through the nuclear export inhibitor, KPT-330, leads to decreased viability and synergy with doxorubicin.
A Klebsiella pneumoniae peptide enters Streptococcus pneumoniae via its AmiA-AliA/AliB permease reducing pneumococcal growth, adherence to primary human airway epithelial cells, colonization of rat nasopharynx and genetic transformation.
The cytogenetic analysis of gonial cells and meiocytes on Korean loach complex suggest that instant switch between sexual to asexual reproduction in hybrids depend on their ploidy and genome dosage.
A study combining microscopy, metabarcoding and metabolomics, along with predicted functions, to investigate the relationships between sponge microbiomes and metabolomics, characterizing four sponges and their distinctive bio-ecological traits.
The authors present a single-cell atlas of human lung samples comprising 45 cell types, which reveals dynamic transcriptional and phenotypic changes associated with development and aging.
A multimodal MRI study analyzes how signals within brain tumors shape the organization of brain networks and predict surgical outcomes with simple machine learning methods.
Direct visualization of synaptic ribbons in neonatal and juvenile mouse cochlea demonstrates that excitotoxic stimulus or noise exposure induces increases in ribbon volume and movement.
A multi-ancestry GWAS meta-analysis of Fuchs endothelial corneal dystrophy identifies eight novel loci, including low-frequency missense variants in laminin genes LAMA5 and LAMB1, and phenome-wide scans uncover pleiotropy with renal traits at TCF4.
This study examines how different odor-learning tasks affect structural plasticity in the olfactory bulb. Sensory deprivation, simple and complex odor learning tasks differently modify the spine density and morphology, revealing tailored plasticity.
A study in zebrafish indicates that elevated cortisol levels during early life can alter the developmental trajectory of the hypothalamus, inducing short-term precocious development, but leading to failed maturation in the long-term.
A study utilizing unsupervised deep learning to generate interpretable brain imaging phenotypes from brain T1 and T2-FLAIR MRI identified 97 genetic loci enhancing understanding of brain structure genetics.
Specification of neuroectoderm from TET3 enzymatic deficient and knockout embryonic stem cells reveals distinct catalytic-dependent and -independent roles of TET3 in activation of neural and suppression of mesodermal programs, respectively.
Use of a cAMP biosensor to study real-time mechano-sensitive enhancement of β2-adrenoceptor constitutive activity and its inhibition by β2-inverse agonists in HEK 293 cells.
A complex Nuclear Receptor Element (cNRE) of 32 base pairs that emerged from a viral infection drives the quail Slow Myosin Heavy Chain III (SMyHC III) promoter preferential expression to the atria.
This study presents a novel mechanism by which androgen receptor (AR) antagonists inhibit the growth of desmoplastic small round cell tumors (DSRCT) independently of AR.
This study proposes a computational panel reduction method for CyCIF, leveraging 9 markers to impute information from 25, enhancing speed, content, and reducing costs.
Presenting mechanisms that modulate cerebral vessel tone as interaction graphs to support research design, interpret study findings, and generate hypotheses on disease.