Browse Articles

  • Article
    | Open Access

    Ceolin et al. optimise the fluorescent protein mNeonGreen to generate a reporter to measure enhancer expression in living Drosophila embryos. They also find that reduced enhancer–promoter distance or addition of binding sites for the pioneer transcription factor Zelda increases enhancer activity.

    • Stefano Ceolin
    • , Monika Hanf
    • , Marta Bozek
    • , Andrea Ennio Storti
    • , Nicolas Gompel
    • , Ulrich Unnerstall
    • , Christophe Jung
    •  & Ulrike Gaul
  • Article
    | Open Access

    Sylvie Gimenez et al. compare adaptation by copy number variation in two geographically distinct populations of the fall armyworm and find a relationship between copy number variation and insecticide resistance. The authors perform toxicological tests to confirm a role of the CYP gene cluster in insecticide resistance and suggest that evolutionary forces causing insecticide resistance can be independent of host-plant adaptation.

    • Sylvie Gimenez
    • , Heba Abdelgaffar
    • , Gaelle Le Goff
    • , Frédérique Hilliou
    • , Carlos A. Blanco
    • , Sabine Hänniger
    • , Anthony Bretaudeau
    • , Fabrice Legeai
    • , Nicolas Nègre
    • , Juan Luis Jurat-Fuentes
    • , Emmanuelle d’Alençon
    •  & Kiwoong Nam
  • Article
    | Open Access

    Lan et al. make single and triple phosphomimetic mutations in a long flexible loop domain of BCL-2 and show that these mutations reduce structural flexibility and promote ligand access to the groove. Their study indicates that changes in structural flexibility on an unstructured loop can activate an allosteric, otherwise inactive protein.

    • Yu-Jing Lan
    • , Pei-Shan Yeh
    • , Te-Yu Kao
    • , Yuan-Chao Lo
    • , Shih-Che Sue
    • , Yu-Wen Chen
    • , Dennis W. Hwang
    •  & Yun-Wei Chiang
  • Article
    | Open Access

    Sato et al. find that WNK (With No Lysine [K]) acts as a positive regulator of the Wnt signaling pathway by attenuating the interaction between β-Catenin and the Glucose Induce degradation Deficient (GID) complex, and show that a WNK inhibitor also functions as a Wnt inhibitor, suppressing xenograft tumor development in mice. These findings suggest that WNK is a regulator of β-Catenin and a potential therapeutic target

    • Atsushi Sato
    • , Masahiro Shimizu
    • , Toshiyasu Goto
    • , Hiroyuki Masuno
    • , Hiroyuki Kagechika
    • , Nobuyuki Tanaka
    •  & Hiroshi Shibuya
  • Article
    | Open Access

    Rosendo-Pineda et al. discover that N-methyl-D-aspartate receptors (NMDAR) mediate transient calcium entry in mitosis, dependent on phosphorylation of NMDAR by Cyclin B1/CDK1. They also find that phosphorylation-mimicking mutants of NMDAR cause mitotic defects, suggesting that precise control of NMDAR-mediated calcium entry is needed for proper mitosis.

    • Margarita Jacaranda Rosendo-Pineda
    • , Juan Jesus Vicente
    • , Oscar Vivas
    • , Jonathan Pacheco
    • , Arlet Loza-Huerta
    • , Alicia Sampieri
    • , Linda Wordeman
    • , Claudia Moreno
    •  & Luis Vaca
  • Article
    | Open Access

    Huang et al. use proteomics to examine liver and liver mitochondria of hibernating bats. The authors observe the unfolded protein response in endoplasmic reticulum and co-activation of survival signaling pathways in torpid bats and provide further insight into physiological adaptations that allow bats to survive a long period of hibernation.

    • Wenjie Huang
    • , Chen-Chung Liao
    • , Yijie Han
    • , Junyan Lv
    • , Ming Lei
    • , Yangyang Li
    • , Qingyun Lv
    • , Dong Dong
    • , Shuyi Zhang
    • , Yi-Husan Pan
    •  & Jian Luo
  • Article
    | Open Access

    By performing an ecologically relevant experiment with variety in litter composition and detritivore species, Joly et al. find that litter conversion into faeces has a profound effect on organic matter lability and decomposition. These findings have implications for biogeochemical models of carbon cycling.

    • François-Xavier Joly
    • , Sylvain Coq
    • , Mathieu Coulis
    • , Jean-François David
    • , Stephan Hättenschwiler
    • , Carsten W. Mueller
    • , Isabel Prater
    •  & Jens-Arne Subke
  • Article
    | Open Access

    By combining whole genome sequencing and metabolomics, Koshiba et al. identify a large number of associations between genetic variants and plasma metabolites. They find that some genetic variants affect the interaction between the host and symbiotic bacteria. This study provides insights into how genetic and environmental factors interact to shape human metabolism.

    • Seizo Koshiba
    • , Ikuko N. Motoike
    • , Daisuke Saigusa
    • , Jin Inoue
    • , Yuichi Aoki
    • , Shu Tadaka
    • , Matsuyuki Shirota
    • , Fumiki Katsuoka
    • , Gen Tamiya
    • , Naoko Minegishi
    • , Nobuo Fuse
    • , Kengo Kinoshita
    •  & Masayuki Yamamoto
  • Article
    | Open Access

    Stephen Doyle et al. report the chromosome-scale genome assembly and transcriptome sequence data of Haemonchus contortus, a key parasitic nematode model. These data show nearly complete conservation of chromosome content with C. elegans and brings insight into transcriptional regulation and chromosome-wide genetic diversity in this important pathogen.

    • Stephen R. Doyle
    • , Alan Tracey
    • , Roz Laing
    • , Nancy Holroyd
    • , David Bartley
    • , Wojtek Bazant
    • , Helen Beasley
    • , Robin Beech
    • , Collette Britton
    • , Karen Brooks
    • , Umer Chaudhry
    • , Kirsty Maitland
    • , Axel Martinelli
    • , Jennifer D. Noonan
    • , Michael Paulini
    • , Michael A. Quail
    • , Elizabeth Redman
    • , Faye H. Rodgers
    • , Guillaume Sallé
    • , Muhammad Zubair Shabbir
    • , Geetha Sankaranarayanan
    • , Janneke Wit
    • , Kevin L. Howe
    • , Neil Sargison
    • , Eileen Devaney
    • , Matthew Berriman
    • , John S. Gilleard
    •  & James A. Cotton
  • Article
    | Open Access

    Branconi et al. report on an experimental approach to investigate the ecological and social drivers of cooperative breeding in clownfish. Experiments were performed on a wild population in Papua New Guinea and indicate that clownfish non-breeding strategies can be understood using economic bargaining theory and cooperative breeding theory.

    • Rebecca Branconi
    • , Tina A. Barbasch
    • , Robin K. Francis
    • , Maya Srinivasan
    • , Geoffrey P. Jones
    •  & Peter M. Buston
  • Article
    | Open Access

    Maria Teschler-Nicola et al. use ancient DNA sequencing to report the earliest known case of human monozygotic twins found in a previously discovered Upper Palaeolithic burial site. Using bioanthropological and archaeological techniques, they also find that the twins were full-term newborns and that ancient mortuary behavior included re-opening of grave sites to bury related individuals together.

    • Maria Teschler-Nicola
    • , Daniel Fernandes
    • , Marc Händel
    • , Thomas Einwögerer
    • , Ulrich Simon
    • , Christine Neugebauer-Maresch
    • , Stefan Tangl
    • , Patrick Heimel
    • , Toni Dobsak
    • , Anika Retzmann
    • , Thomas Prohaska
    • , Johanna Irrgeher
    • , Douglas J. Kennett
    • , Iñigo Olalde
    • , David Reich
    •  & Ron Pinhasi
  • Article
    | Open Access

    Osakabe et al. report the implementation of a CRISPR type I-D (TiD) system for editing in plants, which consists of eight Cas genes (Cas1d–Cas7d, Cas10d) followed by an array of repeat spacer units. The CRISPR TiD can effectively induce short indels, long-range deletions and bi-allelic mutations in plants, adding a valuable toolbox to manipulate plant genomes.

    • Keishi Osakabe
    • , Naoki Wada
    • , Tomoko Miyaji
    • , Emi Murakami
    • , Kazuya Marui
    • , Risa Ueta
    • , Ryosuke Hashimoto
    • , Chihiro Abe-Hara
    • , Bihe Kong
    • , Kentaro Yano
    •  & Yuriko Osakabe
  • Article
    | Open Access

    Shark cells are difficult to culture in the laboratory as the high osmolality physiological conditions do not reflect those of commonly cultured mammalian or teleost fish cell lines. Uno et al. present a new method of culturing shark fibroblasts and lymphocytes, and characterized the karyotypes of four carpet shark species, enabling whole genome analysis of these species.

    • Yoshinobu Uno
    • , Ryo Nozu
    • , Itsuki Kiyatake
    • , Nobuyuki Higashiguchi
    • , Shuji Sodeyama
    • , Kiyomi Murakumo
    • , Keiichi Sato
    •  & Shigehiro Kuraku
  • Article
    | Open Access

    Hyo-Jun Lee et al. show that submergence in Arabidopsis deactivates wound-induced defence against herbivore attack by suppressing the expression of jasmonic acid biosynthesis genes and increasing expression of ethylene-responsive genes. These results shed light on how flooding may impact plant defence systems.

    • Hyo-Jun Lee
    • , Ji-Sun Park
    • , Seung Yong Shin
    • , Sang-Gyu Kim
    • , Gisuk Lee
    • , Hyun-Soon Kim
    • , Jae Heung Jeon
    •  & Hye Sun Cho
  • Article
    | Open Access

    Stuhr and Curran profile the metabolic, lifespan and health outcomes of C. elegans under six bacterial diets: the three most commonly used E. coli strains OP50, HT115, HB101, along with Methylobacterium, Xanthomonas, and Sphingomonas. These results show how diet can differentially alter multiple life history traits including development, reproduction, and metabolism, and can provide a better understanding of the complexities of bacterial diets and subsequent changes in physiology and gene expression.

    • Nicole L. Stuhr
    •  & Sean P. Curran
  • Article
    | Open Access

    The Doushantuo biota of China is incredibly important for understanding the evolution of complex animals. Willman et al. report on evidence of Doushantuo-like biota from the Ediacaran of North Greenland, indicating that these important organisms were distributed across multiple palaeocontinents.

    • Sebastian Willman
    • , John S. Peel
    • , Jon R. Ineson
    • , Niels H. Schovsbo
    • , Elias J. Rugen
    •  & Robert Frei
  • Article
    | Open Access

    Strack et al find that Polymerase δ interacting protein 38 (PDIP38) is targeted to the mitochondrial matrix where it colocalises with the mitochondrial AAA + protein CLPXP. PDIP38 modulates the specificity of CLPXP in vitro and alters the stability of CLPX in vitro and in cells. The PDIP38 structure leads the authors to speculate that PDIP38 is a CLPXP adaptor.

    • Philip R. Strack
    • , Erica J. Brodie
    • , Hanmiao Zhan
    • , Verena J. Schuenemann
    • , Liz J. Valente
    • , Tamanna Saiyed
    • , Bradley R. Lowth
    • , Lauren M. Angley
    • , Matthew A. Perugini
    • , Kornelius Zeth
    • , Kaye N. Truscott
    •  & David A. Dougan
  • Article
    | Open Access

    Beatson et al. show that a sialylated tumour-associated glycoform of the mucin MUC1 induces the differentiation of monocytes into tumour-associated macrophages. These macrophages are found in breast cancer stroma and their presence is associated with poor prognosis.

    • Richard Beatson
    • , Rosalind Graham
    • , Fabio Grundland Freile
    • , Domenico Cozzetto
    • , Shichina Kannambath
    • , Ester Pfeifer
    • , Natalie Woodman
    • , Julie Owen
    • , Rosamond Nuamah
    • , Ulla Mandel
    • , Sarah Pinder
    • , Cheryl Gillett
    • , Thomas Noll
    • , Ihssane Bouybayoune
    • , Joyce Taylor-Papadimitriou
    •  & Joy M. Burchell
  • Article
    | Open Access

    Workenhe et al. show in mice that a combination of oncolytic HSV-1 virus and Mitomycin-C activates an inflammatory response, through necroptosis induction, that renders tumours susceptible to immune checkpoint inhibitors. These findings informs on the potential role of necroptosis in immunotherapy approaches.

    • Samuel T. Workenhe
    • , Andrew Nguyen
    • , David Bakhshinyan
    • , Jiarun Wei
    • , David N. Hare
    • , Kelly L. MacNeill
    • , Yonghong Wan
    • , Andrew Oberst
    • , Jonathan L. Bramson
    • , Jalees A. Nasir
    • , Alyssa Vito
    • , Nader El-Sayes
    • , Sheila K. Singh
    • , Andrew G. McArthur
    •  & Karen L. Mossman
  • Research Highlight
    | Open Access

    While much of the work examining the ecological effects of marine warming events focuses on the magnitude and duration of elevated temperatures, a recent study from Amatzia Genin and colleagues investigates how the rate of onset of warming affects the mortality of reef fish in the Red Sea. These authors document fish mortality following two warming events with dramatic increases in temperature and report that piscivores and benthic grazers were disproportionately represented among the found carcasses. Many of these fish were infected with a bacterial pathogen following the warming event. This study points to the rate of warming increase as a critical parameter to be considered when assessing the ecological effects of marine warming events, including those for which the peak temperature is not anomalous.

    • Caitlin Karniski
  • Article
    | Open Access

    The authors report a single cell-resolution gene expression atlas for the developing mouse liver and gallbladder using a transgenic Foxa2eGFP mouse line. By tracing the development of cells from gut endoderm to hepatoblasts they identify key transcriptional changes during liver specification.

    • Tianhao Mu
    • , Liqin Xu
    • , Yu Zhong
    • , Xinyu Liu
    • , Zhikun Zhao
    • , Chaoben Huang
    • , Xiaofeng Lan
    • , Chengchen Lufei
    • , Yi Zhou
    • , Yixun Su
    • , Luang Xu
    • , Miaomiao Jiang
    • , Hongpo Zhou
    • , Xinxin Lin
    • , Liang Wu
    • , Siqi Peng
    • , Shiping Liu
    • , Susanne Brix
    • , Michael Dean
    • , Norris R. Dunn
    • , Kenneth S. Zaret
    • , Xin-Yuan Fu
    •  & Yong Hou
  • Article
    | Open Access

    Gowripalan, Smith et al. use CRISPR/Cas9 technology to rapidly select recombinant poxviruses without using selectable marker genes. They find that Cas9 cleavage inhibits poxvirus DNA replication, suppressing virus spread in culture. This application makes poxviruses more attractive vector platforms for fighting cancer and emerging disease outbreaks.

    • Anjali Gowripalan
    • , Stewart Smith
    • , Tijana Stefanovic
    •  & David C. Tscharke
  • Article
    | Open Access

    Nirav Chhabra et al. characterize adult mice carrying a homozygous mutation in Pax6 that was identified in a patient with foveal hypoplasia. They find that the Pax6 point mutation has pleiotropic effects, including defects in the mouse retinal structures, loss of the optic nerve, changes in energy metabolism and circadian rhythms, and dysregulation of genes expressed in the pancreas.

    • Nirav Florian Chhabra
    • , Oana Veronica Amarie
    • , Moya Wu
    • , Anna-Lena Amend
    • , Marina Rubey
    • , Daniel Gradinger
    • , Martin Irmler
    • , Johannes Beckers
    • , Birgit Rathkolb
    • , Eckhard Wolf
    • , Annette Feuchtinger
    • , Peter Huypens
    • , Raffaele Teperino
    • , Jan Rozman
    • , Gerhard K. H. Przemeck
    •  & Martin Hrabě de Angelis
  • Article
    | Open Access

    Ruhlandt et al. report a plasmonic nanocavity-based method to measure absolute values of quantum yield of commonly used fluorescent proteins. The method is calibration-free, does not require knowledge about maturation or potential dark states, and works on minute amounts of sample. Authors are further able to determine lifetime and quantum yield of several fluorescent proteins, which would be a good resource for researchers working with them.

    • Daja Ruhlandt
    • , Martin Andresen
    • , Nickels Jensen
    • , Ingo Gregor
    • , Stefan Jakobs
    • , Jörg Enderlein
    •  & Alexey I. Chizhik
  • Article
    | Open Access

    Joseph Korpela et al. demonstrate the use of machine-learning assisted bio-loggers on black-tailed gulls and streaked shearwaters. As video recording is only activated through variations in movement detected by low-cost accelerometers, this method represents improvements to runtime and precision over existing bio-logging technology.

    • Joseph Korpela
    • , Hirokazu Suzuki
    • , Sakiko Matsumoto
    • , Yuichi Mizutani
    • , Masaki Samejima
    • , Takuya Maekawa
    • , Junichi Nakai
    •  & Ken Yoda
  • Article
    | Open Access

    Lee et al. describe the generation of aglycosylated antibody-producing mice. These aglycosylated antibodies, lacking glycans prevent unwanted interactions with the lectins, and are used as reagents in a tool they developed called ALIQUAT. This aglycosylated antibody and lectin-based immunoassay diagnostic platform can be used to detect disease specific glycan biomarkers.

    • Nan-Ee Lee
    • , Sun Hee Kim
    • , Dae-Yeul Yu
    • , Eui-Jeon Woo
    • , Myung-Il Kim
    • , Gi-Sang Seong
    • , Sun Min Lee
    • , Jeong-Heon Ko
    •  & Yong-Sam Kim
  • Article
    | Open Access

    Zhang et al. characterize the functions of two distinct arginine kinase genes in flour beetles. Using RNA interference and electophoretic mobility shift assays, they identify Broad-Complex transcription factor as the mediator of opposing hormonal regulation in these genes.

    • Nan Zhang
    • , Heng Jiang
    • , Xiangkun Meng
    • , Kun Qian
    • , Yaping Liu
    • , Qisheng Song
    • , David Stanley
    • , Jincai Wu
    • , Yoonseong Park
    •  & Jianjun Wang
  • Article
    | Open Access

    Shi et al. use solid-state nuclear magnetic resonance spectroscopy to reveal the internal dynamics of human histones hH3 and hH4 in the Widom 601 and the telomeric nucleosome core particles. This work has implications for the propagation of epigenetic changes via the center of the nucleosome core communicating with histone tails and DNA.

    • Xiangyan Shi
    • , Chinmayi Prasanna
    • , Aghil Soman
    • , Konstantin Pervushin
    •  & Lars Nordenskiöld
  • Article
    | Open Access

    Iain Timmins et al. identify 70 loci associated with self-reported walking pace in the UK Biobank. Using Mendelian randomization, they find evidence for a causal link between increased walking pace and lower cardiometabolic risk profile, which combined with a low estimated heritability, suggests self-reported walking pace could be a target for healthcare intervention.

    • Iain R. Timmins
    • , Francesco Zaccardi
    • , Christopher P. Nelson
    • , Paul W. Franks
    • , Thomas Yates
    •  & Frank Dudbridge
  • Article
    | Open Access

    Seo et al. identify fatty acid-binding protein 5 (FABP5) as a booster of HIF-1α activity. They find that oleic-acid treatment activates the FABP5/HIF-1α axis, promoting lipid accumulation and cell proliferation in liver cancer cells. This study provides insights into how fatty acids drive the progression of cancer.

    • Jieun Seo
    • , Do-Won Jeong
    • , Jong-Wan Park
    • , Kwang-Woong Lee
    • , Junji Fukuda
    •  & Yang-Sook Chun
  • Article
    | Open Access

    Blumental-Perry et al. find that exposure to cigarette smoke causes the redistribution of the mitochondria-encoded non-codling RNA, mito-ncR-805, from mitochondria to the nucleus in alveolar epithelial cells. This relocation event correlates with increased expression of nuclear genes involved in mitochondrial function, suggesting that this response has a protective role.

    • A. Blumental-Perry
    • , R. Jobava
    • , I. Bederman
    • , A. J. Degar
    • , H. Kenche
    • , B. J. Guan
    • , K. Pandit
    • , N. A. Perry
    • , N. D. Molyneaux
    • , J. Wu
    • , E. Prendergas
    • , Z.-W. Ye
    • , J. Zhang
    • , C. E. Nelson
    • , F. Ahangari
    • , D. Krokowski
    • , S. H. Guttentag
    • , P. A. Linden
    • , D. M. Townsend
    • , A. Miron
    • , M.-J. Kang
    • , N. Kaminski
    • , Y. Perry
    •  & M. Hatzoglou
  • Article
    | Open Access

    Scarola et al. identify a conserved OCT4 pseudogene mechanism of action and demonstrate that the OCT4 pseudogene lncRNA is required for FUS-dependent loading of the SUV39H1 histone methyltransferase to the promoter of the parental OCT4 gene.

    • Michele Scarola
    • , Elisa Comisso
    • , Massimo Rosso
    • , Giannino Del Sal
    • , Claudio Schneider
    • , Stefan Schoeftner
    •  & Roberta Benetti
  • Article
    | Open Access

    Yang, Xu, Gu et al. demonstrate that activation of endogenous Sox17 pushes fibroblasts to an extraembryonic endoderm-like state in chemically induced reprogramming of somatic cells into stem cells. This study provides insights into how chemicals prime the transition of somatic cells into stem cells.

    • Zhenghao Yang
    • , Xiaochan Xu
    • , Chan Gu
    • , Jun Li
    • , Qihong Wu
    • , Can Ye
    • , Alexander Valentin Nielsen
    • , Lichao Mao
    • , Junqing Ye
    • , Ke Bai
    • , Fan Guo
    • , Chao Tang
    •  & Yang Zhao
  • Article
    | Open Access

    Ku, Kim et al develop a method to analyse the ratio of the alternatively spliced variant of AIMP2 to full length AIMP via single-molecule RNA-FISH. They can subclassify hematologic cancer based on AIMP2-DX2/AIMP2 ratio and find that cells with high AIMP2-DX2 ratio can be sensitized to chemotherapy drugs by depleting AIMP2-DX2.

    • Jayoung Ku
    • , Ryul Kim
    • , Dongchan Kim
    • , Daeyoon Kim
    • , Seulki Song
    • , Keonyong Lee
    • , Namseok Lee
    • , MinA Kim
    • , Sung-Soo Yoon
    • , Nam Hoon Kwon
    • , Sunghoon Kim
    • , Yoosik Kim
    •  & Youngil Koh
  • Article
    | Open Access

    Casali, Tognolina et al. use two-photon laser microscopy to spatially map long-term synaptic plasticity in rat cerebellar granular cells following stimulation of mossy fibers. Their data allow them to apply realistic modeling to test hypotheses about the synaptic spiking dynamics and reveal the importance of synaptic inhibition to defining these microcircuits.

    • Stefano Casali
    • , Marialuisa Tognolina
    • , Daniela Gandolfi
    • , Jonathan Mapelli
    •  & Egidio D’Angelo
  • Article
    | Open Access

    Kimura et al. reports a refined human skin equivalent (HSE) model that reproduces traction-force balance in the lateral direction. This tension improves HSE characteristics and promotes skin homeostasis. This model has great potential for applications in drug screening and understanding the molecular mechanisms of drug effects, skin ageing and diseases.

    • Shun Kimura
    • , Ayako Tsuchiya
    • , Miho Ogawa
    • , Miki Ono
    • , Nao Suda
    • , Kaori Sekimoto
    • , Makoto Takeo
    •  & Takashi Tsuji
  • Article
    | Open Access

    Lindsay Stewart et al. analyze clinical isolates of the human malaria parasite Plasmodium falciparum from a highly endemic West African population and show that intrinsic multiplication rate variation is associated with blood-stage infection intensity. Their results indicate that parasite control of multiplication contributes to virulence.

    • Lindsay B. Stewart
    • , Ofelia Diaz-Ingelmo
    • , Antoine Claessens
    • , James Abugri
    • , Richard D. Pearson
    • , Sonia Goncalves
    • , Eleanor Drury
    • , Dominic P. Kwiatkowski
    • , Gordon A. Awandare
    •  & David J. Conway
  • Article
    | Open Access

    Amanda Melin et al. compare variation in 29 primate species at 12 amino acid residue sites coded by the ACE2 gene and show that apes and African and Asian monkeys exhibit the same set of twelve key amino acid residues as human ACE2. These results suggest that these primates are likely to be susceptible to SARS-CoV-2, whereas ACE2 gene sequences and protein-protein interaction models suggest reduced susceptibility for platyrrhines, tarsiers, lorisoids, and some lemurs.

    • Amanda D. Melin
    • , Mareike C. Janiak
    • , Frank Marrone III
    • , Paramjit S. Arora
    •  & James P. Higham
  • Article
    | Open Access

    Hechenleitner et al. describe two new titanosaurians and the finding of numerous accumulations of titanosaurian eggs in La Rioja, Argentina. This study suggests nesting site philopatry among Titanosauria and that this clade was spread throughout southern South America at the end of the Late Cretaceous.

    • E. Martín Hechenleitner
    • , Léa Leuzinger
    • , Agustín G. Martinelli
    • , Sebastián Rocher
    • , Lucas E. Fiorelli
    • , Jeremías R. A. Taborda
    •  & Leonardo Salgado
  • Article
    | Open Access

    Bleasdale et al. examine the introduction of agricultural crops in the Congo Basin with stable isotope analysis of human and animal remains, charred food remains, and plant microparticles from dental calculus. Their findings reveal variation in the adoption of cereals from the early Iron Age, and provide long-term insights into changing human reliance on different resources.

    • Madeleine Bleasdale
    • , Hans-Peter Wotzka
    • , Barbara Eichhorn
    • , Julio Mercader
    • , Amy Styring
    • , Jana Zech
    • , María Soto
    • , Jamie Inwood
    • , Siobhán Clarke
    • , Sara Marzo
    • , Bianca Fiedler
    • , Veerle Linseele
    • , Nicole Boivin
    •  & Patrick Roberts
  • Article
    | Open Access

    Honma et al. have developed a method of producing high-sugar rice grains using gene knock-out technology. This grain has the potential to advance development of alternative sugar crops in the future.

    • Yujiro Honma
    • , Prakash Babu Adhikari
    • , Keiko Kuwata
    • , Tomoko Kagenishi
    • , Ken Yokawa
    • , Michitaka Notaguchi
    • , Kenichi Kurotani
    • , Erika Toda
    • , Kanako Bessho-Uehara
    • , Xiaoyan Liu
    • , Shaowei Zhu
    • , Xiaoyan Wu
    •  & Ryushiro D. Kasahara
  • Article
    | Open Access

    Kozlovskii and Popov present BiteNet, a new computational method utilizing deep learning principles for rapid detection of binding sites. BiteNet considers proteins as 3D images, enabling rapid detection of allosteric sites from either static protein structures or its dynamic ensembles.

    • Igor Kozlovskii
    •  & Petr Popov
  • Author Correction
    | Open Access

    • Jacob Beal
    • , Natalie G. Farny
    • , Traci Haddock-Angelli
    • , Vinoo Selvarajah
    • , Geoff S. Baldwin
    • , Russell Buckley-Taylor
    • , Markus Gershater
    • , Daisuke Kiga
    • , John Marken
    • , Vishal Sanchania
    • , Abigail Sison
    • , Christopher T. Workman
    • , Meryem Pehlivan
    • , Biel Badia Roige
    • , Tiu Aarnio
    • , Samu Kivisto
    • , Jessica Koski
    • , Leevi Lehtonen
    • , Denise Pezzutto
    • , Pauliina Rautanen
    • , Weixin Bian
    • , Zhiyuan Hu
    • , Zhihao Liu
    • , Zi Liu
    • , Liang Ma
    • , Luyao Pan
    • , Zichen Qin
    • , Huichao Wang
    • , Xiangxuan Wang
    • , Hao Xu
    • , Xia Xu
    • , Yorgo El Moubayed
    • , Shan Dong
    • , Choco Fang
    • , Hanker He
    • , Henry He
    • , Fangliang Huang
    • , Ruyi Shi
    • , Cassie Tang
    • , Christian Tang
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  • Article
    | Open Access

    Brell, Berg et al find that iron enters cells not only through iron-transferrin uptake by the transferrin receptor (CD71) but also through uptake of heme-albumin by this receptor and that heme-albumin stimulates proliferation in a manner dependent on heme oxygenase 1. This study presents a new route for iron uptake in mammalian cells.

    • Brell Jennifer
    • , Verena Berg
    • , Madhura Modak
    • , Alexander Puck
    • , Maria Seyerl-Jiresch
    • , Sarojinidevi Künig
    • , Gerhard J. Zlabinger
    • , Peter Steinberger
    • , Janet Chou
    • , Raif S. Geha
    • , Leopold Öhler
    • , Akihiro Yachie
    • , Hyeryun Choe
    • , Markus Kraller
    • , Hannes Stockinger
    •  & Johannes Stöckl