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A mesocosm heating experiment reveals that corals stressed by bleaching and/or heating exude compositionally distinct dissolved organic matter, which in turn yields elevated microbial loads and may increase abundance of copiotrophic and putatively pathogenic bacterioplankton on stressed coral reefs.
Tir, a bacterial effector, exploits host-like disorder to rewire cellular processes via dimerization, lipid binding, and phosphorylation, revealing a versatile intracellular strategy for infection.
Mouse genetics indicates that serine hydroxymethyltransferase 2 maintains hepatic methylation potential and plays stage-specific roles in the pathogenesis of non-alcoholic fatty liver disease.
Systematic culture and genome sequencing of thoracic airway commensal bacteria finds many potential influences on lung health and disease. Polyomics of differentiated airway epithelium also suggest pathways that may sustain host-microbial interactions.
A Mendelian Randomization study with 36,211 mother-child pairs indicates that maternal genetic variants, influencing a child’s birth weight, impact the child’s risk for common diseases through inheritance and not by effects on intrauterine growth.
High resolution mass spectrometry (HRMS) is a powerful tool to simultaneously quantify multiple isotopes. A software package was created to analyze HRMS data from transient isotopic labeling experiments to deduce active metabolic pathways.
The cryo-EM structure of the partially Ca2 + -bound light-harvesting 1–reaction center (LH1–RC) complex from Alc. vinosum, the best-studied model purple sulfur bacterium, is presented, characterized and compared to other photosynthetic bacteria.
A study on genetic diversity and multiple pathogen infections in wild rodents and reservoir hosts shows human habitat disturbance also adversely affects generalist species by limiting their adaptive potential and facilitating pathogen spill-over.
A study of mussel populations in Scottish waters found that mussel larvae move from south to north and form five distinct genetic groups. This helps preserve mussel farms and marine ecosystems.
Functional analysis of Cdc20 motifs in a clean background generated by combining CRISPR/Cas9 and RNAi reveals a critical role of the CRY box in the mitotic checkpoint signaling.
Analysis of fMRI data from participants in a probability estimation task suggests that the parieto-occipital cortex is a neural substrate for humans’ ability to approximate Bayesian inference by integrating prior beliefs with new information.
The bacterial T3SS effector YfiD interacts with the catalytic domain of host PARP1 during infection. Inhibition of PARP1 activity impairs the pro-inflammatory response against bacterial infection.
A protein-agnostic bioinformatic tool is capable of predicting transcription factor:DNA interactions, facilitating genome mining for chemical-inducible synthetic biology sensors.
Physiological and molecular studies have shown that 3,4-dichlorophenylacetic acid (Dcaa) has auxin-like activity and acts through the auxin signaling pathway in plants. This provides a basis for the application of Dcaa in agricultural practice.
Synchrotron X-ray imaging of stimulated human middle ears reveals the 3D movement of auditory ossicles: it enables their motion quantification, confirms the lever-like motions of the malleus and incus and reveals a more intricate stapedial behavior.
This study reports RNA recognition by hMEX3B via NMR, SAXS and MD simulation methods. The authors also investigated hMEX3B functions both in vitro and in vivo and proposed how hMEX3B promotes tumor immune escape by regulating the HLA-A.
A single-cell RNA sequencing study about POP constructed a transcriptional profile of 30,452 single cells of the uterosacral ligament in human for the first time, revealing a picture of immune cell infiltration in USL tissue of POP samples.
The anatomy of the Drosophila female lower reproductive tract is probed using a combination of high-resolution correlative three-dimensional imaging techniques, highlighting aspects of seminal receptacle sperm interactions and sperm viability.
Cells stretch to thin films through the use of a nanostructured membrane. Analysis of the thin film interference colors of the stretched cells allows simultaneous measurement of the specimens’ pointwise thickness and refractive index.