Early detection of risk factors and signs of cardiovascular disease is an important component of cardiovascular-health promotion. Nature Reviews Cardiology is thus holding a session on this topic at the World Heart Federation's 2010 World Congress of Cardiology in Beijing, China. Review articles that accompany the five talks in this session are published in the June 2010 issue of Nature Reviews Cardiology.
REVIEWS
Early identification of cardiovascular risk using genomics and proteomics
Iftikhar J. Kullo & Leslie T. Cooper
doi:10.1038/nrcardio.2010.53
Nature Reviews Cardiology 7, 309-317 (2010)
In this Review, Drs. Kullo and Cooper discuss the role of genomics and proteomics in cardiovascular risk assessment, using the specific example of atherosclerosis. The availability of good markers for risk stratification might enable the health-care system to become more proactive, moving the focus away from treatment of end-stage coronary heart disease and towards early detection of disease risk and prevention of adverse outcomes.
Early identification of risk factors for sudden cardiac death
Sumeet S. Chugh
doi:10.1038/nrcardio.2010.52
Nature Reviews Cardiology 7, 318-326 (2010)
Sudden cardiac death (SCD) is a serious health concern worldwide. Despite the need for risk factors that can identify high-risk individuals, there are few available owing to the complex and often asymptomatic nature of SCD. In this Review, Sumeet Chugh outlines novel risk markers and predictors of SCD that will allow more effective prevention, and suggests a framework for studies in the future for the discovery and validation of these risk markers.
Early identification of atherosclerotic disease by noninvasive imaging
Valentin Fuster, Fátima Lois & Manuel Franco
doi:10.1038/nrcardio.2010.54
Nature Reviews Cardiology 7, 327-333 (2010)
Current strategies for prevention of cardiovascular disease (CVD) are focused on identifying individuals at high risk by recognizing and managing established cardiovascular risk factors. Early detection of subclinical atherosclerosis is a promising opportunity for CVD prevention. In this article, the authors review the role of noninvasive imaging techniques in understanding the mechanisms of atherosclerosis and in identifying early stages of disease, and highlight their potential impact on CVD prevention.
Early detection of myocardial dysfunction and heart failure
Geoffrey de Couto, Maral Ouzounian & Peter P. Liu
doi:10.1038/nrcardio.2010.51
Nature Reviews Cardiology 7, 334-344 (2010)
To date, treatment strategies for heart failure have focused on the symptomatic stage of disease, often after irreversible remodeling and functional impairment have occurred. Early identification of cardiac dysfunction would allow implementation of early intervention strategies to delay the progression or to prevent the onset of heart failure altogether. This Review highlights the utility of a staged approach for patients with predisposing risk factors, which uses serological biomarkers followed by noninvasive imaging techniques.
Early management of atrial fibrillation: from imaging to drugs to ablation
Ashok J. Shah, Xingpeng Liu, Amir S. Jadidi & Michel Haïssaguerre
doi:10.1038/nrcardio.2010.49
Nature Reviews Cardiology 7, 345-354 (2010)
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Early management of this disorder using imaging, antiarrhythmia drugs and catheter ablation is necessary to prevent the progression of AF. In this Review, the authors discuss the current status of important facets of the early management of AF and emphasize the need for a greater understanding of the underlying etiology, which will lead to novel treatment approaches and amelioration of AF.
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