More than 50% of patients with chronic heart failure present with iron deficiency, which is associated with reduced quality of life and worse prognosis. Intravenous iron supplementation therapy has been shown to improve clinical outcomes in these patients.

High plasma levels of HDL cholesterol have been shown to be associated with a lower risk of cardiovascular disease. However, paradoxically, very high HDL-cholesterol levels are associated with increased mortality in patients with coronary artery disease, according to a new study.

The stretch-activated, calcium-permeable Piezo1 channel is the mechanosensor that transduces cardiomyocyte stretch into the biochemical signalling pathway that leads to cardiac hypertrophy in mice.

Important lessons about human susceptibility to coronary atherosclerosis can be learned from the relative resilience of chimpanzees to coronary artery disease (CAD), despite their higher baseline plasma levels of LDL cholesterol and lipoprotein(a) than in humans. Evolutionary pressure and hyper-reactive T cells might have a role in the unique susceptibility of humans to CAD.

Adding remnant cholesterol levels to traditional risk scores for ischaemic heart disease and myocardial infarction improves the accuracy of individual risk stratification.

Gene therapy targeting the protein trafficking regulator MOG1 successfully reversed clinical features of Brugada syndrome in a knock-in mouse model.