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EDITOR'S CHOICE
As one of the newest additions to the NPG portfolio, The Journal of Antibiotics is proud to present the Editor's Choice – a collection of articles spanning the scope of the journal and featuring these five topics: new anti-infective substances; structure determination/chemical synthesis; new bioactive substances (other than anti-infective); microbial genetics/biosynthesis; and microbiology/fermentation/resistance.
New bioactive substances (other than anti-infective) |
structure determination / chemical synthesis |
Microbial genetics / biosynthesis |
New Anti-infective Substances
Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144
I. Taxonomy, Fermentation, Isolation and Structural Elucidation FREE
Atsushi Fukumoto, Yong-Pil Kim, Atsuko Matsumoto, Yoko Takahashi, Kazuro Shiomi, Hiroshi Tomoda and Satoshi Ōmura
J. Antibiot. 61: 1–6; doi:10.1038/ja.2008.101 (2008)
Cyslabdan, a New Potentiator of Imipenem Activity against Methicillin-resistant Staphylococcus aureus, Produced by Streptomyces sp. K04-0144
II. Biological Activities FREE
Atsushi Fukumoto, Yong-Pil Kim, Hideaki Hanaki, Kazuro Shiomi, Hiroshi Tomoda and Satoshi Ōmura
J. Antibiot. 61: 7–10; doi:10.1038/ja.2008.102 (2008)
Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509
II. Physico-chemical Properties and Structure Elucidation FREE
Masato Iwatsuki, Ryuji Uchida, Hitomi Yoshijima, Hideaki Ui, Kazuro Shiomi, Yong-Pil Kim, Tomoyasu Hirose, Toshiaki Sunazuka, Akio Abe, Hiroshi Tomoda and Satoshi Ōmura
J. Antibiot. 61: 230–236; doi:10.1038/ja.2008.33 (2008)
New Bioactive Substances (other than anti-infective)
RK-95113, a New Angiogenesis Inhibitor Produced by Aspergillus fumigatus FREE
Yukihiro Asami, Hideaki Kakeya, Gen Okada, Masakazu Toi and Hiroyuki Osada
J. Antibiot. 59: 724–728; doi:10.1038/ja.2006.97 (2006)
SAR Study of a Novel Triene-ansamycin Group Compound, Quinotrierixin, and Related Compounds, as Inhibitors of ER Stress-induced XBP1 Activation
I. Taxonomy, Fermentation, Isolation, Biological Activities and SAR Study FREE
Tatsuro Kawamura, Etsu Tashiro, Kohta Yamamoto, Kazutoshi Shindo and Masaya Imoto
J. Antibiot. 61: 303–311; doi:10.1038/ja.2008.43 (2008)
Structure Determination / Chemical Synthesis
YCM1008A, a Novel Ca2+-Signaling Inhibitor, Produced by Fusarium sp. YCM1008 FREE
Fumito Koizumi, Naomi Fukumitsu, Jinrong Zhao, Ruthada Chanklan, Tokichi Miyakawa, Shoko Kawahara, Shin Iwamoto, Makoto Suzuki, Shingo Kakita, Endang S. Rahayu, Seijiro Hosokawa, Kuniaki Tatsuta and Michio Ichimura
J. Antibiot. 60: 455–458; doi:10.1038/ja.2007.58 (2007)
Guadinomines, Type III Secretion System Inhibitors, Produced by Streptomyces sp. K01-0509
I. Taxonomy, Fermentation, Isolation and Biological Properties FREE
Masato Iwatsuki, Ryuji Uchida, Hitomi Yoshijima, Hideaki Ui, Kazuro Shiomi, Atsuko Matsumoto, Yoko Takahashi, Akio Abe, Hiroshi Tomoda and Satoshi Ōmura
J. Antibiot. 61: 222–229; doi:10.1038/ja.2008.32 (2008)
Microbial Genetics / Biosynthesis
Generation of New Epothilones by Genetic Engineering of a Polyketide Synthase in Myxococcus xanthus FREE
Li Tang, Loleta Chung, John R. Carney, Courtney M. Starks, Peter Licari and Leonard Katz
J. Antibiot. 58: 178–184; doi:10.1038/ja.2005.20 (2005)
Isolation and Identification of Three New 5-Alkenyl-3,3(2H)-furanones from Two Streptomyces species using a Genomic Screening Approach FREE
Arjun H. Banskota, James B. McAlpine, Dan Sørensen, Mustapha Aouidate, Mahmood Piraee, Anne-Marie Alarco, Satoshi Omura, Kazuro Shiomi, Chris M. Farnet and Emmanuel Zazopoulos
J. Antibiot. 59: 168–176; doi:10.1038/ja.2006.24 (2006)
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