Recent progress in the study of cellular mechanotransduction — the conversion of mechanical forces into biochemical signals — has increased our understanding of mechanobiology by providing novel insights into how mechanical inputs regulate cell behaviour and tissue homeostasis and how their deregulation might cause disease. This Focus issue includes Review articles and comments that discuss how mechanical forces are transduced into the cell, including into the nucleus, to control gene expression and to regulate morphogenesis, tissue regeneration and tumorigenesis. Also discussed is the therapeutic potential of modulating mechanotransduction with the use of synthetic matrices.


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