Focus
Focus on Ciliogenesis
Cilia have emerged as key organelles that modulate developmental and physiological processes. Cilia protrude from the cell and are composed of a central microtubule-based structure essential for their movement, surrounded by a specialized membrane. This particular organization requires the coordination between cytoskeletal and membrane traffic-related processes. Cilia-generated flow is involved in left-right determination, influences the outcome of several signalling pathways in development, and is essential for the normal function of many organs. Given this diversity of functions, defects in ciliogenesis have been linked to a wide range of pathologies: from brain hydrocephaly and failures in mucus clearance (both directly dependent on the motile properties of cilia) to retinal degeneration and defects in kidney function (involving ciliary signalling roles). This web focus comprises a collection of research articles published in Nature Cell Biology over the past four years and highlights our current knowledge on key aspects of ciliogenesis and its importance for development and normal physiology.
Research
A size-exclusion permeability barrier and nucleoporins characterize a ciliary pore complex that regulates transport into cilia
Hooi Lynn Kee, John F. Dishinger, T. Lynne Blasius, Chia-Jen Liu, Ben Margolis and Kristen J. Verhey
DOI: 10.1038/ncb2450; Nature Cell Biology 14, 431–437; (2012)
Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation
J. L. Stubbs, E. K. Vladar, J. D. Axelrod and C. Kintner
DOI: 10.1038/ncb2406; Nature Cell Biology 14, 140–147; (2012)
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain
Ben Chih, Peter Liu, Yvonne Chinn, Cecile Chalouni, Laszlo G. Komuves, Philip E. Hass, Wendy Sandoval & Andrew S. Peterson
DOI: 10.1038/ncb2410; Nature Cell Biology 14, 61–72; (2012)
Ciliary transition zone activation of phosphorylated Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors
Li, AQ; Saito, M; Chuang, JZ; Tseng, YY; Dedesma, C; Tomizawa, K; Kaitsuka, T and Sung, CH
DOI: 10.1038/ncb2218; Nature Cell Biology 13, 402–411; (2011)
Intraflagellar transport delivers tubulin isotypes to sensory cilium middle and distal segments-
Hao, LM; Thein, M; Brust-Mascher, I; Civelekoglu-Scholey, G; Lu, Y; Acar, S; Prevo, B; Shaham, S and Scholey, JM
DOI: 10.1038/ncb2268; Nature Cell Biology 13, 790–798; (2011)
Nde1-mediated inhibition of ciliogenesis affects cell cycle re-entry-
Kim, S; Zaghloul, NA; Bubenshchikova, E; Oh, EC; Rankin, S; Katsanis, N; Obara, T and Tsiokas, L
DOI: 10.1038/ncb2183; Nature Cell Biology 13, 38–45; (2011)
Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway-
Marcet, B; Chevalier, B; Luxardi, G; Coraux, C; Zaragosi, LE; Cibois, M; Robbe-Sermesant, K; Jolly, T; Cardinaud, B; Moreilhon, C; Giovannini-Chami, L; Nawrocki-Raby, B; Birembaut, P; Waldmann, R; Kodjabachian, L and Barbry, P
DOI: 10.1038/ncb2241; Nature Cell Biology 13, 693–699; (2011)
Subcellular spatial regulation of canonical Wnt signalling at the primary cilium-
Lancaster, MA; Schroth, J and Gleeson, JG
DOI: 10.1038/ncb2259; Nature Cell Biology 13, 700–707; (2011)
Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia-
Guirao, B; Meunier, A; Mortaud, S; Aguilar, A; Corsi, JM; Strehl, L; Hirota, Y; Desoeuvre, A; Boutin, C; Han, YG; Mirzadeh, Z; Cremer, H; Montcouquiol, M; Sawamoto, K and Spassky, N
DOI: 10.1038/ncb2040; Nature Cell Biology 12, 341–350; (2010)
Planar polarization of node cells determines the rotational axis of node cilia
Hashimoto, M; Shinohara, K; Wang, JB; Ikeuchi, S; Yoshiba, S; Meno, C; Nonaka, S; Takada, S; Hatta, K; Wynshaw-Boris, A and Hamada, H
DOI: 10.1038/ncb2020; Nature Cell Biology 12, 170–176; (2010)
Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta 2 and RanGTP-
Dishinger, JF; Kee, HL; Jenkins, PM; Fan, SL; Hurd, TW; Hammond, JW; Truong, YNT; Margolis, B; Martens, JR and Verhey, KJ
DOI: 10.1038/ncb2073; Nature Cell Biology 12, 703–710; (2010)
Primary cilia regulate mTORC1 activity and cell size through Lkb1
Boehlke, C; Kotsis, F; Patel, V; Braeg, S; Voelker, H; Bredt, S; Beyer, T; Janusch, H; Hamann, C; Godel, M; Muller, K; Herbst, M; Hornung, M; Doerken, M; Kottgen, M; Nitschke, R; Igarashi, P; Walz, G and Kuehn, EW
DOI: 10.1038/ncb2117; Nature Cell Biology 12, 1115–1122; (2010)
Vangl2 directs the posterior tilting and asymmetric localization of motile primary cilia-
Borovina, A; Superina, S; Voskas, D and Ciruna, B
DOI: 10.1038/ncb2042; Nature Cell Biology 12, 407–412; (2010)
The planar cell polarity effector Fuz is essential for targeted membrane trafficking, ciliogenesis and mouse embryonic development
Ryan S. Gray, Philip B. Abitua, Bogdan J. Wlodarczyk, Heather L. Szabo-Rogers, Otis Blanchard, Insuk Lee, Greg S. Weiss, Karen J. Liu, Edward M. Marcotte, John B. Wallingford & Richard H. Finnell
DOI: 10.1038/ncb1966; Nature Cell Biology 11, 1225–1232; (2009)
elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8
Yoshihiro Omori, Chengtian Zhao, Arunesh Saras, Saikat Mukhopadhyay, Woong Kim, Takahisa Furukawa, Piali Sengupta, Alexey Veraksa and Jarema Malicki
DOI: 10.1038/ncb1706; Nature Cell Biology 10, 437–444; (2008)
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