Translation and protein quality control

Our understanding of the complex regulation of protein synthesis and its integration with other steps of gene expression such as mRNA decay has dramatically increased. Furthermore, we are gaining important insights into the quality-control mechanisms that ensure the correct co-translational folding of proteins and their targeting to specific cell compartments. In this series of Reviews we focus on the mechanisms that control translation, protein quality control and related cellular processes, and reveal how their deregulation affects ageing and diseases such as cancer, neurodegeneration and infectious diseases.