Focus 04 March 2016

Soft Tissue

The heterogeneity and relative rarity of soft tissue sarcomas make them challenging targets for classification, biomarker identification, and development of improved treatment strategies. Laboratory Investigation and Modern Pathology are pleased to present a collection of recent articles that enhance our understanding of the pathogenesis of these tumors and describe advances that may lead to the development of new diagnostic tests and targeted therapies.

Content

Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma
- Fiorella Faggi
- Nicola Chiarelli
- Alessandro Fanzani
Research Article30 Mar 2015 Laboratory Investigation
RNA sequencing of sarcomas with simple karyotypes: identification and enrichment of fusion transcripts
- Jakob Hofvander
- Johnbosco Tayebwa
- Fredrik Mertens
Research Article13 Apr 2015 Laboratory Investigation
Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors
- Anne E Sarver
- Aaron L Sarver
- Subbaya Subramanian
Research Article29 Jun 2015 Laboratory Investigation
A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway
- Masayuki Tsuneki
- Steven Hardee
- Joseph A Madri
Research Article11 May 2015 Laboratory Investigation
Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing
- Charles Walther
- Jakob Hofvander
- Fredrik Mertens
Research Article29 Jun 2015 Laboratory Investigation
Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-κB regulatory genes
- Gabriel K Griffin
- Lynette M Sholl
- Jason L Hornick
Original Article13 Nov 2015 Modern Pathology
Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics
- Inga-Marie Schaefer
- Christopher DM Fletcher
- Jason L Hornick
Original Article20 Nov 2015 Modern Pathology
BCOR–CCNB3 fusions are frequent in undifferentiated sarcomas of male children
- Tricia L Peters
- Vijetha Kumar
- Angshumoy Roy
Original Article31 Oct 2014 Modern Pathology
Fluorescence in situ hybridization analysis is a helpful test for the diagnosis of dermatofibrosarcoma protuberans
- Marie Karanian
- Gaëlle Pérot
- Agnès Neuville
Original Article1 Aug 2014 Modern Pathology
CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression
- Steven Christopher Smith
- Darya Buehler
- Rajiv M Patel
Original Article20 Jun 2014 Modern Pathology
NY-ESO-1 (CTAG1B) expression in mesenchymal tumors
- Makoto Endo
- Marieke A de Graaff
- Torsten O Nielsen
Original Article21 Nov 2014 Modern Pathology
Prognostic relevance of Fédération Nationale des Centres de Lutte Contre le Cancer grade and MDM2 amplification levels in dedifferentiated liposarcoma: a study of 50 cases
- George Jour
- Ashley Gullet
- Benjamin L Hoch
Original Article25 Jul 2014 Modern Pathology
Nuclear expression and gain-of-function β-catenin mutation in glomangiopericytoma (sinonasal-type hemangiopericytoma): insight into pathogenesis and a diagnostic marker
- Jerzy Lasota
- Anna Felisiak-Golabek
- Markku Miettinen
Original Article28 Nov 2014 Modern Pathology
Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas
- Jen-Chieh Lee
- Yung-Ming Jeng
- Ching-Yao Yang
Original Article29 May 2015 Modern Pathology
Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas
- Jau-Yu Liau
- Jen-Chieh Lee
- Yung-Ming Jeng
Original Article2 Oct 2015 Modern Pathology
Liposarcomas of the posterior mediastinum: clinicopathologic study of 18 cases
- Pablo Ortega
- David Suster
- Saul Suster
Original Article5 Dec 2014 Modern Pathology
MicroRNAs in the pathobiology of sarcomas
- Anne E Sarver
- Subbaya Subramanian
Mini Review29 Jun 2015 Laboratory Investigation
A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas
- Peter Y Yu
- Mumtaz Y Balkhi
- O Hans Iwenofu
Technical Report15 Feb 2016 Laboratory Investigation

Soft Tissue

Content

Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma

RNA sequencing of sarcomas with simple karyotypes: identification and enrichment of fusion transcripts

Identification, by systematic RNA sequencing, of novel candidate biomarkers and therapeutic targets in human soft tissue tumors

A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway

Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencing

Targeted genomic sequencing of follicular dendritic cell sarcoma reveals recurrent alterations in NF-κB regulatory genes

Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics

BCOR–CCNB3 fusions are frequent in undifferentiated sarcomas of male children

Fluorescence in situ hybridization analysis is a helpful test for the diagnosis of dermatofibrosarcoma protuberans

CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression

NY-ESO-1 (CTAG1B) expression in mesenchymal tumors

Prognostic relevance of Fédération Nationale des Centres de Lutte Contre le Cancer grade and MDM2 amplification levels in dedifferentiated liposarcoma: a study of 50 cases

Nuclear expression and gain-of-function β-catenin mutation in glomangiopericytoma (sinonasal-type hemangiopericytoma): insight into pathogenesis and a diagnostic marker

Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas

Comprehensive screening of alternative lengthening of telomeres phenotype and loss of ATRX expression in sarcomas

Liposarcomas of the posterior mediastinum: clinicopathologic study of 18 cases

MicroRNAs in the pathobiology of sarcomas

A selective screening platform reveals unique global expression patterns of microRNAs in a cohort of human soft-tissue sarcomas

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