FOCUS
For hierarchy
CUTTING EDGE ISSUES IN IMMUNOLOGY AND AUTOIMMUNITY
In recent decades enormous effort has been made to elucidate the pathogenesis of autoimmune and autoinflammatory diseases. Autoimmunity is a multifactorial process in which genetic, immunological, environmental and hormonal factors act in concert, representing what was termed some years ago the “mosaic of autoimmunity”. The May 2011 Special Issue on Cutting Edge Issues in Immunology and Autoimmunity summarizes our current understanding of this complex mosaic. The accompanying selection of recent articles from across the Springer Nature provide further insight into this topic.
Reviews
Immunity to fungal infections
Luigina Romani
Nature Reviews Immunology, advance online publication, doi:10.1038/nri2939
State of the union between metabolism and the immune system in type 2 diabetes FREE
B S Nikolajczyk, M Jagannathan-Bogdan, H Shin and R Gyurko
Genes Immun, advance online publication, doi:10.1038/gene.2011.14
Shifting the balance: antibiotic effects on host–microbiota mutualism
Benjamin P. Willing, Shannon L. Russell and B. Brett Finlay
Nature Reviews Microbiology 9, 233-243, doi:10.1038/nrmicro2536
Emerging inflammasome effector mechanisms
Mohamed Lamkanfi
Nature Reviews Immunology 11, 213-220, doi:10.1038/nri2936
Immunomodulatory effects of anti-angiogenic drugs FREE
A Heine, S A E Held, A Bringmann, T A W Holderried and P Brossart
Leukemia, advance online publication, doi:10.1038/leu.2011.24
MicroRNAs: the fine-tuners of Toll-like receptor signalling
Luke A. O'Neill, Frederick J. Sheedy and Claire E. McCoy
Nature Reviews Immunology 11, 163-175, doi:10.1038/nri2957
Articles
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells
Erika Cretney, Annie Xin, Wei Shi, Martina Minnich, Frederick Masson, Maria Miasari, Gabrielle T Belz, Gordon K Smyth, Meinrad Busslinger, Stephen L Nutt and Axel Kallies
Nature Immunology, advance online publication, doi:10.1038/ni.2006
The helminth product ES-62 protects against septic shock via Toll-like receptor 4–dependent autophagosomal degradation of the adaptor MyD88
Padmam Puneet, Mairi A McGrath, Hwee Kee Tay, Lamyaa Al-Riyami, Justyna Rzepecka, Shabbir M Moochhala, Shazib Pervaiz, Margaret M Harnett, William Harnett and Alirio J Melendez
Nature Immunology, advance online publication, doi:10.1038/ni.2004
Chromatin remodeling resets the immune system to protect against autoimmune diabetes in mice FREE
Tejas Patel, Vasu Patel, Rajvir Singh and Sundararajan Jayaraman
Immunol Cell Biol, advance online publication, doi:10.1038/icb.2010.144
partner of 
