Scientific Reports

Collection 06 March 2024

Cell & Molecular Biology Top 100 of 2023

This collection highlights the most downloaded* cell and molecular biology research papers published by Scientific Reports in 2023. Featuring authors from around the world, these papers highlight valuable research from an international community.

You can also view the journal's overall Top 100 or the Top 100 within various subject areas.

*Data obtained from SN Insights, which is based on Digital Science’s Dimensions.

1-25

Modulating heart rate oscillation affects plasma amyloid beta and tau levels in younger and older adults
- Jungwon Min
- Jeremy Rouanet
- Mara Mather
ArticleOpen Access9 Mar 2023 Scientific Reports
Fetal bovine serum, an important factor affecting the reproducibility of cell experiments
- Shuai Liu
- Wei Yang
- Changqing Sun
ArticleOpen Access2 Feb 2023 Scientific Reports
Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3
- Yunfeng Li
- Yulia Pustovalova
- Bing Hao
ArticleOpen Access18 Feb 2023 Scientific Reports
Enhanced presynaptic mitochondrial energy production is required for memory formation
- Erica L. Underwood
- John B. Redell
- Pramod K. Dash
ArticleOpen Access2 Sep 2023 Scientific Reports
Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction
- Elizabeth England
- D. Gareth Rees
- E. Suzanne Cohen
ArticleOpen Access17 Jun 2023 Scientific Reports
RNA-binding proteins that lack canonical RNA-binding domains are rarely sequence-specific
- Debashish Ray
- Kaitlin U. Laverty
- Timothy R. Hughes
ArticleOpen Access31 Mar 2023 Scientific Reports
CRISPR imaging reveals chromatin fluctuation at the centromere region related to cellular senescence
- Hideaki Takata
- Yumena Masuda
- Nobuko Ohmido
ArticleOpen Access5 Sep 2023 Scientific Reports
Integrated multi-omics analysis of Alzheimer’s disease shows molecular signatures associated with disease progression and potential therapeutic targets
- Pradeep Kodam
- R. Sai Swaroop
- Ramakrishna Vadrevu
ArticleOpen Access6 Mar 2023 Scientific Reports
Rejuvenating effects of young extracellular vesicles in aged rats and in cellular models of human senescence
- Lilian Grigorian Shamagian
- Russell G. Rogers
- Eduardo Marbán
ArticleOpen Access28 Jul 2023 Scientific Reports
Direct cell extraction of membrane proteins for structure–function analysis
- Ieva Drulyte
- Aspen Rene Gutgsell
- Robin Löving
ArticleOpen Access25 Jan 2023 Scientific Reports
Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy
- Guillaume A. Castillon
- Sebastien Phan
- Mark H. Ellisman
ArticleOpen Access5 Dec 2023 Scientific Reports
Spatial subcellular organelle networks in single cells
- Mythreye Venkatesan
- Nicholas Zhang
- Ahmet F. Coskun
ArticleOpen Access1 Apr 2023 Scientific Reports
Food protein-derived amyloids do not accelerate amyloid β aggregation
- M. Mahafuzur Rahman
- Rodrigo Sanches Pires
- Christofer Lendel
ArticleOpen Access31 Jan 2023 Scientific Reports
Single-cell-led drug repurposing for Alzheimer’s disease
- Silvia Parolo
- Federica Mariotti
- Enrico Domenici
ArticleOpen Access5 Jan 2023 Scientific Reports
Effects of a monoclonal antibody against (pro)renin receptor on gliomagenesis
- Takeshi Fujimori
- Yuki Shibayama
- Keisuke Miyake
ArticleOpen Access16 Jan 2023 Scientific Reports
Stem cells-derived exosomes alleviate neurodegeneration and Alzheimer’s pathogenesis by ameliorating neuroinflamation, and regulating the associated molecular pathways
- Muhammad Imran Khan
- Eun Sun Jeong
- Jong Deog Kim
ArticleOpen Access21 Sep 2023 Scientific Reports
A hybrid in silico/in-cell controller for microbial bioprocesses with process-model mismatch
- Tomoki Ohkubo
- Yuki Soma
- Katsuyuki Kunida
ArticleOpen Access4 Sep 2023 Scientific Reports
Mitochondrial impairment but not peripheral inflammation predicts greater Gulf War illness severity
- Beatrice A. Golomb
- Roel Sanchez Baez
- Hemal H. Patel
ArticleOpen Access12 Jul 2023 Scientific Reports
Natural and engineered mediators of desiccation tolerance stabilize Human Blood Clotting Factor VIII in a dry state
- Maxwell H. Packebush
- Silvia Sanchez-Martinez
- Thomas C. Boothby
ArticleOpen Access20 Mar 2023 Scientific Reports
Cryo-EM structure of a catalytic amyloid fibril
- Thomas Heerde
- Akanksha Bansal
- Marcus Fändrich
ArticleOpen Access11 Mar 2023 Scientific Reports
Computational analysis of the sequence-structure relation in SARS-CoV-2 spike protein using protein contact networks
- Pietro Hiram Guzzi
- Luisa di Paola
- Pierangelo Veltri
ArticleOpen Access17 Feb 2023 Scientific Reports
Activation of L-lactate oxidase by the formation of enzyme assemblies through liquid–liquid phase separation
- Tomoto Ura
- Ako Kagawa
- Tsutomu Mikawa
ArticleOpen Access25 Jan 2023 Scientific Reports
DNA hypomethylation characterizes genes encoding tissue-dominant functional proteins in liver and skeletal muscle
- Hideki Maehara
- Toshiya Kokaji
- Shinya Kuroda
ArticleOpen Access5 Nov 2023 Scientific Reports
Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4
- Chandru Gajendran
- Shoichi Fukui
- Dhanalakshmi Sivanandhan
ArticleOpen Access23 Feb 2023 Scientific Reports
Variability of fluorescence intensity distribution measured by flow cytometry is influenced by cell size and cell cycle progression
- Radek Fedr
- Zuzana Kahounová
- Karel Souček
ArticleOpen Access25 Mar 2023 Scientific Reports

26-50

CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death
- Sofia Pavlou
- Stefanie Foskolou
- Emmanouil Metzakopian
ArticleOpen Access9 Mar 2023 Scientific Reports
Fluorescence Lifetime Imaging Microscopy (FLIM) reveals spatial-metabolic changes in 3D breast cancer spheroids
- Kavon Karrobi
- Anup Tank
- Darren Roblyer
ArticleOpen Access3 Mar 2023 Scientific Reports
Induction of psoriasis- and atopic dermatitis-like phenotypes in 3D skin equivalents with a fibroblast-derived matrix
- Bianka Morgner
- Jörg Tittelbach
- Cornelia Wiegand
ArticleOpen Access31 Jan 2023 Scientific Reports
Effects of imeglimin on mitochondrial function, AMPK activity, and gene expression in hepatocytes
- Kaori Hozumi
- Kenji Sugawara
- Wataru Ogawa
ArticleOpen Access13 Jan 2023 Scientific Reports
Correlation analysis of sperm DNA fragmentation index with semen parameters and the effect of sperm DFI on outcomes of ART
- KangSheng Liu
- XiaoDong Mao
- Ruifang An
ArticleOpen Access15 Feb 2023 Scientific Reports
A highly sensitive NanoLuc-based protease biosensor for detecting apoptosis and SARS-CoV-2 infection
- Masashi Arakawa
- Akiho Yoshida
- Eiji Morita
ArticleOpen Access31 Jan 2023 Scientific Reports
Different electrostatic forces drive the binding kinetics of SARS-CoV, SARS-CoV-2 and MERS-CoV Envelope proteins with the PDZ2 domain of ZO1
- Valeria Pennacchietti
- Angelo Toto
ArticleOpen Access16 May 2023 Scientific Reports
Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease
- Dezhao Li
- Yaoshan Dun
- Suixin Liu
ArticleOpen Access11 Aug 2023 Scientific Reports
Chronic exposure to warm temperature causes low sperm abundance and quality in Drosophila melanogaster
- Ana Caroline P. Gandara
- Daniela Drummond-Barbosa
ArticleOpen Access30 Jul 2023 Scientific Reports
Intercorrelated variability in blood and hemodynamic biomarkers reveals physiological network in hemodialysis patients
- Yuichi Nakazato
- Masahiro Shimoyama
- Hiromi Shimoyama
ArticleOpen Access30 Jan 2023 Scientific Reports
Drug cytotoxicity screening using human intestinal organoids propagated with extensive cost-reduction strategies
- Yu Takahashi
- Yu Inoue
- Ryuichiro Sato
ArticleOpen Access3 Apr 2023 Scientific Reports
The evaluation of tumorigenicity and characterization of colonies in a soft agar colony formation assay using polymerase chain reaction
- Daichi Nakamura
ArticleOpen Access3 Apr 2023 Scientific Reports
Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids
- Md Soriful Islam
- Maclaine Parish
- James H. Segars
ArticleOpen Access25 May 2023 Scientific Reports
Mechanical stimuli activate gene expression via a cell envelope stress sensing pathway
- Christine E. Harper
- Wenyao Zhang
- Christopher J. Hernandez
ArticleOpen Access26 Aug 2023 Scientific Reports
Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats
- Nicolas G. Glynos
- Lily Carter
- Jimo Borjigin
ArticleOpen Access6 Jan 2023 Scientific Reports
Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer’s disease
- Masoud Rahmati
- Mohammad Shariatzadeh Joneydi
- Yusheng Li
ArticleOpen Access13 Feb 2023 Scientific Reports
The identification of metabolites from gut microbiota in NAFLD via network pharmacology
- Ki-Kwang Oh
- Haripriya Gupta
- Ki Tae Suk
ArticleOpen Access13 Jan 2023 Scientific Reports
Heat denaturation enables multicolor X10-STED microscopy
- Kim Ann Saal
- Ali H. Shaib
- Silvio O. Rizzoli
ArticleOpen Access1 Apr 2023 Scientific Reports
Glutamine synthetase (GS) knockout (KO) using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodies
- Witsanu Srila
- Martina Baumann
- Montarop Yamabhai
ArticleOpen Access28 Jun 2023 Scientific Reports
Simplifying the detection and monitoring of protein glycosylation during in vitro glycoengineering
- Matthew J. Saunders
- Robert J. Woods
- Loretta Yang
ArticleOpen Access11 Jan 2023 Scientific Reports
Polyunsaturated fatty acids-rich dietary lipid prevents high fat diet-induced obesity in mice
- Yuri Haneishi
- Yuma Furuya
- Junki Miyamoto
ArticleOpen Access5 Apr 2023 Scientific Reports
Immature and mature bone marrow-derived dendritic cells exhibit distinct intracellular mechanical properties
- Antoine Leblanc-Hotte
- Cindy Audiger
- Sylvie Lesage
ArticleOpen Access3 Feb 2023 Scientific Reports
Design of an artificial phage-display library based on a new scaffold improved for average stability of the randomized proteins
- M. Gomes
- A. Fleck
- M. Valerio-Lepiniec
ArticleOpen Access24 Jan 2023 Scientific Reports
IL-6/ERK signaling pathway participates in type I IFN-programmed, unconventional M2-like macrophage polarization
- Limin Yang
- Panpan Guo
- Jianghuai Liu
ArticleOpen Access1 Feb 2023 Scientific Reports
Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling
- Mayumi Shono
- Keiko Kishimoto
- Katsuhiko Hayashi
ArticleOpen Access23 Feb 2023 Scientific Reports

51-75

β-Aminoisobutyric acid (L-BAIBA) is a novel regulator of mitochondrial biogenesis and respiratory function in human podocytes
- Irena Audzeyenka
- Maria Szrejder
- Agnieszka Piwkowska
ArticleOpen Access14 Jan 2023 Scientific Reports
In silico and in vitro studies confirm Ondansetron as a novel acetylcholinesterase and butyrylcholinesterase inhibitor
- Asma Gholami
- Dariush Minai-Tehrani
- Leif A. Eriksson
ArticleOpen Access12 Jan 2023 Scientific Reports
FUS regulates a subset of snoRNA expression and modulates the level of rRNA modifications
- Kishor Gawade
- Patrycja Plewka
- Katarzyna D. Raczynska
ArticleOpen Access20 Feb 2023 Scientific Reports
Rapid clonal identification of biallelic CRISPR/Cas9 knock-ins using SNEAK PEEC
- Sameer Singh
- Anoosha Banerjee
- Sebastian Klinge
ArticleOpen Access31 Jan 2023 Scientific Reports
PepCNN deep learning tool for predicting peptide binding residues in proteins using sequence, structural, and language model features
- Abel Chandra
- Alok Sharma
- Abdul Sattar
ArticleOpen Access28 Nov 2023 Scientific Reports
Characterisation of a cyclic peptide that binds to the RAS binding domain of phosphoinositide 3-kinase p110α
- Mohamed Ismail
- Stephen R. Martin
- Julian Downward
ArticleOpen Access2 Feb 2023 Scientific Reports
Purified complement C3b triggers phagocytosis and activation of human neutrophils via complement receptor 1
- Elena Boero
- Ronald D. Gorham Jr.
- Suzan H. M. Rooijakkers
ArticleOpen Access6 Jan 2023 Scientific Reports
Structural characterisation of hemagglutinin from seven Influenza A H1N1 strains reveal diversity in the C05 antibody recognition site
- Seyed Mohammad Ghafoori
- Gayle F. Petersen
- Jade K. Forwood
ArticleOpen Access28 Apr 2023 Scientific Reports
Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation
- Shoko Hashimoto
- Yukio Matsuba
- Takaomi C. Saido
ArticleOpen Access20 Jan 2023 Scientific Reports
Integrated multi-omics analysis reveals the molecular interplay between circadian clocks and cancer pathogenesis
- Andy Pérez-Villa
- Gabriela Echeverría-Garcés
- Andrés López-Cortés
ArticleOpen Access30 Aug 2023 Scientific Reports
Nicotinamide mononucleotide (NMN) alleviates the poly(I:C)-induced inflammatory response in human primary cell cultures
- Hitomi Sano
- Anton Kratz
- Ayako Yachie
ArticleOpen Access20 Jul 2023 Scientific Reports
TMS-EEG perturbation biomarkers for Alzheimer’s disease patients classification
- Alexandra-Maria Tăuƫan
- Elias P. Casula
- Emiliano Santarnecchi
ArticleOpen Access11 May 2023 Scientific Reports
Initiation and modulation of Tau protein phase separation by the drug suramin
- Prabhu Rajaiah Prince
- Janine Hochmair
- Christian Betzel
ArticleOpen Access9 Mar 2023 Scientific Reports
Development of a novel air–liquid interface airway tissue equivalent model for in vitro respiratory modeling studies
- Timothy Leach
- Uma Gandhi
- Sean V. Murphy
ArticleOpen Access22 Jun 2023 Scientific Reports
Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs
- Ryu Kawada
- Tatsuya Jonouchi
- Hidetoshi Sakurai
ArticleOpen Access11 Jan 2023 Scientific Reports
Once a week consumption of Western diet over twelve weeks promotes sustained insulin resistance and non-alcoholic fat liver disease in C57BL/6 J mice
- Thainá Magalhães Demaria
- Leticia Diniz Crepaldi
- Mauro Sola-Penna
ArticleOpen Access21 Feb 2023 Scientific Reports
Efficient production of recombinant proteins in suspension CHO cells culture using the Tol2 transposon system coupled with cycloheximide resistance selection
- Keina Yamaguchi
- Risa Ogawa
- Koichi Kawakami
ArticleOpen Access10 May 2023 Scientific Reports
Collagen constitutes about 12% in females and 17% in males of the total protein in mice
- Katharina Tarnutzer
- Devanarayanan Siva Sankar
- Collin Y. Ewald
ArticleOpen Access18 Mar 2023 Scientific Reports
A randomized, open-label clinical trial in mild cognitive impairment with EGb 761 examining blood markers of inflammation and oxidative stress
- Xavier Morató
- Marta Marquié
- Mercè Boada
ArticleOpen Access3 Apr 2023 Scientific Reports
Butyrate limits human natural killer cell effector function
- Vanessa Zaiatz-Bittencourt
- Fiona Jones
- Elizabeth J. Ryan
ArticleOpen Access15 Feb 2023 Scientific Reports
Apoptotic gene loss in Cnidaria is associated with transition to parasitism
- Alexander M. Neverov
- Alexander Y. Panchin
- Yuri V. Panchin
ArticleOpen Access17 May 2023 Scientific Reports
A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection
- Diana Romero-Zamora
- Makoto T. Hayashi
ArticleOpen Access12 Jan 2023 Scientific Reports
Structural insights into the bi-specific cross-over dual variable antibody architecture by cryo-EM
- David Fernandez-Martinez
- Mark D. Tully
- Eaazhisai Kandiah
ArticleOpen Access29 May 2023 Scientific Reports
A highly efficient scheme for library preparation from single-stranded DNA
- Fumihito Miura
- Hideaki Kanzawa-Kiriyama
- Takashi Ito
ArticleOpen Access25 Aug 2023 Scientific Reports
Integrated network pharmacology and experimental validation to explore the mechanisms underlying naringenin treatment of chronic wounds
- Rui Sun
- Chunyan Liu
- Yibing Wang
ArticleOpen Access4 Jan 2023 Scientific Reports

76-100

Substrate stiffness controls proinflammatory responses in human gingival fibroblasts
- Watcharaphol Tiskratok
- Masahiro Yamada
- Hiroshi Egusa
ArticleOpen Access24 Jan 2023 Scientific Reports
Gut inflammation associated with age and Alzheimer’s disease pathology: a human cohort study
- Margo B. Heston
- Kendra L. Hanslik
- Tyler K. Ulland
ArticleOpen Access14 Nov 2023 Scientific Reports
Human PNPase causes RNA stabilization and accumulation of R-loops in the Escherichia coli model system
- Federica A. Falchi
- Francesca Forti
- Federica Briani
ArticleOpen Access21 Jul 2023 Scientific Reports
Coenzyme A binding sites induce proximal acylation across protein families
- Chris Carrico
- Andrew Cruz
- Eric Verdin
ArticleOpen Access28 Mar 2023 Scientific Reports
Modeling and affinity maturation of an anti-CD20 nanobody: a comprehensive in-silico investigation
- Alireza Poustforoosh
- Sanaz Faramarz
- Hassan Hashemipour
ArticleOpen Access11 Jan 2023 Scientific Reports
A multidimensional ODE-based model of Alzheimer’s disease progression
- Matías Nicolás Bossa
- Hichem Sahli
ArticleOpen Access23 Feb 2023 Scientific Reports
Inner mitochondrial membrane protein Prohibitin 1 mediates Nix-induced, Parkin-independent mitophagy
- Kibrom M. Alula
- Yaritza Delgado-Deida
- Arianne L. Theiss
ArticleOpen Access2 Jan 2023 Scientific Reports
Ceramide releases exosomes with a specific miRNA signature for cell differentiation
- Federico Fiorani
- Rossana Domenis
- Elisabetta Albi
ArticleOpen Access7 Jul 2023 Scientific Reports
The spatial distribution of GPCR and Gβγ activity across a cell dictates PIP3 dynamics
- Dhanushan Wijayaratna
- Kasun Ratnayake
- Ajith Karunarathne
ArticleOpen Access16 Feb 2023 Scientific Reports
Establishment of a 96-well transwell system using primary human gut organoids to capture multiple quantitative pathway readouts
- Charles W. Wright
- Naomi Li
- Sina Mohammadi
ArticleOpen Access29 Sep 2023 Scientific Reports
HA-tag CD63 is a novel conditional transgenic approach to track extracellular vesicle interactions with sperm and their transfer at conception
- Christopher P. Morgan
- Victoria E. Meadows
- Tracy L. Bale
ArticleOpen Access13 Jan 2023 Scientific Reports
Development of a three-dimensional organoid model to explore early retinal phenotypes associated with Alzheimer’s disease
- Sailee S. Lavekar
- Jade Harkin
- Jason S. Meyer
ArticleOpen Access24 Aug 2023 Scientific Reports
Determining the structure of the bacterial voltage-gated sodium channel NaChBac embedded in liposomes by cryo electron tomography and subtomogram averaging
- Shih-Ying Scott Chang
- Patricia M. Dijkman
- Misha Kudryashev
ArticleOpen Access17 Jul 2023 Scientific Reports
Mechanism of rotenone binding to respiratory complex I depends on ligand flexibility
- Caroline S. Pereira
- Murilo H. Teixeira
- Guilherme M. Arantes
ArticleOpen Access25 Apr 2023 Scientific Reports
Modelling ligand depletion for simultaneous affinity and binding site quantification on cells and tissue
- Judith Weber
- Klara Djurberg
- Sina Bondza
ArticleOpen Access20 Jun 2023 Scientific Reports
Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy
- Hannah C. Zierden
- Ruth Marx-Rattner
- Tracy L. Bale
ArticleOpen Access20 Mar 2023 Scientific Reports
Modulation of transcription factor dynamics allows versatile information transmission
- Alan Givré
- Alejandro Colman-Lerner
- Silvina Ponce Dawson
ArticleOpen Access14 Feb 2023 Scientific Reports
Meta-analysis of NAD(P)(H) quantification results exhibits variability across mammalian tissues
- Dassine Azouaoui
- Michael René Choinière
- Keir J. Menzies
ArticleOpen Access11 Feb 2023 Scientific Reports
Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1
- Rhianna J. Rowland
- Richard Heath
- Marco Salamina
ArticleOpen Access3 Jul 2023 Scientific Reports
Multimodal perturbation analyses of cyclin-dependent kinases reveal a network of synthetic lethalities associated with cell-cycle regulation and transcriptional regulation
- Kyle Ford
- Brenton P. Munson
- Trey Ideker
ArticleOpen Access11 May 2023 Scientific Reports
A simple method to make, trap and deform a vesicle in a gel
- Pierre Tapie
- Alexis M. Prevost
- Elie Wandersman
ArticleOpen Access2 Apr 2023 Scientific Reports
Heat shock protein A2 is a novel extracellular vesicle-associated protein
- Damian Robert Sojka
- Agata Abramowicz
- Dorota Scieglinska
ArticleOpen Access23 Mar 2023 Scientific Reports
Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis
- Frances M. Bashore
- Ariana B. Marquez
- Alison D. Axtman
ArticleOpen Access14 Apr 2023 Scientific Reports
Increasing the melting temperature of VHH with the in silico free energy score
- Yusuke Tomimoto
- Rika Yamazaki
- Hiroki Shirai
ArticleOpen Access25 Mar 2023 Scientific Reports
Oxidative stress induces mitochondrial iron overload and ferroptotic cell death
- Yi Chen
- Xiaoyun Guo
- Qinghang Liu
ArticleOpen Access19 Sep 2023 Scientific Reports

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