Gene therapy for cancer
- Submission status
- Open
- Submission deadline
Gene therapy is a therapeutic method that modifies an individual’s genes to correct an underlying genetic problem. Cancer is often described as a genetic disease, with many cancers being driven by specific genetic lesions. Therefore, gene therapy might be particularly useful in treating cancer. Gene therapy can take many forms in cancer: gene editing can be used restore mutated oncogenes or tumor suppressors, suicide gene therapy can be used to promote cancer cell apoptosis, and T cells can be engineered for precision therapy through the introduction of chimeric antigens. Clinically, however, few gene-editing treatments have been approved for use in cancer patients, indicating the need for more research into this therapeutic modality.
This Collection welcomes original research examining gene therapy in cancer, including preclinical and clinical studies on gene editing and delivery and chimeric antigen receptor T cells.
Editors
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Mariangela Garofalo
PhD, MBA, University of Padova, Italy
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Dumitru Andrei Iacobas
PhD, Prairie View A&M University, USA
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Weidong Xiao
PhD, Indiana University, USA
