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10th Anniversary of LSA: Collection on Biophotonics and Medical Optics
2022 marks the 10th anniversary of Light: Science & Applications (LSA). In the past decade, LSA has published hundreds of outstanding researches covering the fundamentals and applications in all areas of optics and photonics. From those published papers, we have picked some on Biophotonics and Medical Optics to share with you, our readers. We hope this collection can stimulate more researches and practices in related fields, and promote further progress in optics and photonics research.
Standardized imaging protocols, data analysis methods, reporting of metrics and trial outcome measures will enhance the impact of OCTA on improving retinal healthcare.
We reported a newly engineered photosensitizer of polymer encapsulated carbonized hemin nanoparticles (P-CHNPs) via a facile synthesis procedure for boosting photodynamic therapy (PDT). The synthesized P-CHNPs achieved enhanced oxidative stress in tumor microenvironment, which could be further amplified under light irradiation, enabling excellent in vitro and in vivo PDT effects. Moreover, the superior in vitro and in vivo biocompatibility and boosted PDT effect make the P-CHNPs a potential therapeutic agent for future translational research.
A self-alignment attention-guided residual-in-residual dense generative adversarial networks architecture closes the gap between speed, field of view, and image quality of label-free nonlinear optical microscopes which are notoriously slow.
A fiber optic probe-based Raman imaging system with real-time molecular virtual reality data visualization of chemical boundaries for clinical tissue-boundary demarcation.
An implantable imaging shank is designed and fabricated which enables multicolor lens-less light-field fluorescence imaging, in addition to measuring fluorescent lifetime through time-correlated single-photon counting.
The review focuses on methodologies and biomedical applications of polarisation optics. It also presents prospects on development trends, the potential multi-modal uses in conjunction with other techniques.
An optical fiber biosensor displaying superfine plasmonic spectral combs and enhanced by conjugate-induced amplification enables the detection of environmental estrogens down to pg/mL estradiol equivalent concentration level.
Moderate light absorption by bio-tissue is conducive to the imaging performance. The second near-infrared window is perfected as 900–1880 nm, and 2080–2340 nm is proposed as the third near-infrared window.
The emerging biological entities-based biophotonic probes, such as biological lasers, biophotonic waveguides, and bio-microlenses, have opened up an entirely new window for bio-detection and imaging with high biocompatibility.
Rapid label-free detection of SARS-CoV-2 using phase imaging (spatial light-interference microscopy (SLIM)) with computational specificity. Different virus types captured in SLIM image are detected and classified by 2D U-Net.