Pancreatobiliary Neoplasms
Neoplastic diseases of the pancreas and the biliary tract share numerous common features regarding their morphology, immunohistochemical profile and molecular driver events. In the last few years, numerous efforts have been made towards standardization of the diagnostic approach to these malignancies and exploration of their biologically relevant pathomechanisms, such as the interaction with the microenvironment. In addition, the integration of immunophenotypical and molecular data into the classical histomorphological approach has led to the definition of new entities and to a clear-cut and more clinically relevant classification of the already known ones.
In this virtual issue we highlight papers from Modern Pathology and Virchows Archiv which deal with the most recent developments in molecular pathogenesis, classification, and diagnosis of pancreatobiliary neoplasms.
Courtesy of Virchows Archiv
Lost in Translation: Confusion on Resection and Dissection Planes Hampers the Interpretation of Pathology Reports for Perihilar Cholangiocarcinoma Roos E, Franken LC, Soer EC, et al.
Sarcomatoid carcinomas of the gallbladder: clinicopathologic characteristics Taskin OC, Akkas G, Memis B, et al.
Immune cell score in pancreatic cancer – comparison of hot spot and whole-section analyses Tahkola K, Leppänen J, Ahtiainen M, et al
c-MYC amplification and c-myc protein expression in pancreatic acinar cell carcinomas. New insights into the molecular signature of these rare cancers La Rosa S, Bernasconi B, Vanoli A, et al.
Tumour origin and R1 rates in pancreatic resections: towards consilience in pathology reporting Bal M, Rane S, Talole S, et al.
High Immune Cell Score Predicts Improved Survival in Pancreatic Cancer Tahkola K, Mecklin J-P, Wirta E-V, et al.
Dilemmas for the pathologist in the oncologic assessment of pancreatoduodenectomy specimens Soer E, Brosens L, van de Vijver M, et al.
DLEC1 methylation is associated with a better clinical outcome in patients with intrahepatic cholangiocarcinoma of the small duct subtype Kim Y, Lee K, Jeong S, et al.
Prognostic role of BAP-1 and PBRM-1 expression in intrahepatic cholangiocarcinoma Sarcognato S, Gringeri E, Fassan M, et al.
EVI1 expression is associated with aggressive behavior in intrahepatic cholangiocarcinoma Tanaka M, Shibahara J, Ishikawa S, et al.
