Mechanisms and actions of ferroptosis
- Submission status
- Open
- Submission deadline
Discovered over a decade ago, ferroptosis is a form of non-apoptotic cell death that depends on the production of reactive oxygen species (ROS), iron and lipid peroxidation. Ferroptosis has been a very attractive research target ever since as it has a central position in cellular (lipid) metabolism and oxidative stress homeostasis and employs several cellular organelles from the endoplasmic reticulum (ER), the Golgi, peroxisomes and lysosomes to mitochondria. Importantly, ferroptosis is implicated in a variety of diseases and pathophysiological conditions of the nervous and cerebrovascular system, kidney repair and cancer, with an attractive avenue for anti-tumour therapy.
For this Collection, we invite submissions on cellular signalling and mechanisms of ferroptosis and its roles in a pathological context. In addition to original research Articles, we will also consider Reviews, Perspectives and Comments covering these topics. All submissions will be subject to the same review process as regular Communications Biology Articles.
This Collection supports and amplifies research related to SDG 3.
