Notch signalling
- Submission status
- Closed
- Submission deadline
Notch signalling is a highly conserved cellular interaction pathway fundamental to metazoan development and homeostasis. When notch, a cell-surface receptor, binds to a ligand on a neighboring cell, the Notch intracellular domain is released and enters the nucleus, where it activates target gene transcription. Despite its simplicity, Notch signalling underlies a wide diversity of processes related to cell fate, differentiation, and death. These include many aspects of embryonic development, particularly in the nervous, cardiovascular, and endocrine systems. It is also critical to homeostatic processes in a range of adult organs and tissues, such as the liver, skin, lungs, intestine, skeletal muscle, vasculature, and the hematopoietic system. Meanwhile, malfunctions in the Notch pathway can lead to cancer progression by promoting tumor vasculature, cancer cell stemness, and cell migration. This diversity of function is enabled by the nuclear context of the cell receiving the signal, as well as the expression patterns of the ligands and receptors.
Articles in this Collection will explore this conserved yet varied pathway and its many roles in development, homeostasis, and pathology.
Editors
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Thimios Mitsiadis
University of Zurich, Switzerland
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Pamela Stanley
Albert Einstein College of Medicine, USA
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Natascia Tiso
University of Padova, Italy
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Maliha Zahid
Mayo Clinic, USA
Submitting a paper for consideration
To submit your manuscript for consideration at Scientific Reports as part of this Collection, please follow the steps detailed on this page. On the first page of our online submission system, under “I’m submitting:” select the option “any other article type”. Once logged in you can submit your manuscript to a Collection by selecting “Guest Edited Collection”, under the “Choose the appropriate manuscript type” message, and clicking “Continue”. Then when filling out the manuscript information, select the "Notch signalling" Collection from the alphabetical list on the “Springer Nature Subject Category” tab. Authors should express their interest in the Collection in their cover letter.
Accepted papers are published on a rolling basis as soon as they are ready.
In addition to papers on Notch signalling, Scientific Reports welcomes all original research in the field of Cell Biology. To browse our latest articles in Cell Biology click here.
