Notch signalling
- Submission status
- Closed
- Submission deadline
Notch signalling is a highly conserved cellular interaction pathway fundamental to metazoan development and homeostasis. When notch, a cell-surface receptor, binds to a ligand on a neighboring cell, the Notch intracellular domain is released and enters the nucleus, where it activates target gene transcription. Despite its simplicity, Notch signalling underlies a wide diversity of processes related to cell fate, differentiation, and death. These include many aspects of embryonic development, particularly in the nervous, cardiovascular, and endocrine systems. It is also critical to homeostatic processes in a range of adult organs and tissues, such as the liver, skin, lungs, intestine, skeletal muscle, vasculature, and the hematopoietic system. Meanwhile, malfunctions in the Notch pathway can lead to cancer progression by promoting tumor vasculature, cancer cell stemness, and cell migration. This diversity of function is enabled by the nuclear context of the cell receiving the signal, as well as the expression patterns of the ligands and receptors.
Articles in this Collection will explore this conserved yet varied pathway and its many roles in development, homeostasis, and pathology.
Editors
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Thimios Mitsiadis
University of Zurich, Switzerland
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Pamela Stanley
Albert Einstein College of Medicine, USA
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Natascia Tiso
University of Padova, Italy
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Maliha Zahid
Mayo Clinic, USA
Thimios Mitsiadis is a Professor at the Institute of Oral Biology of the University of Zurich. He conducts research in the fields of stem cells, genetics, molecular and experimental biology related to orofacial developmental and regeneration processes. He aims to understand the regulatory mechanisms and cell fate decisions during organ development and tissue regeneration mainly through the Notch signalling pathway. Professor Mitsiadis has been an Editorial Board Member for Scientific Reports since 2019.
Pamela Stanley holds the Howard W. Goldsmith Foundation Chair and is Professor of Cell Biology at the Albert Einstein College of Medicine in New York. Her laboratory has revealed key roles in Notch signaling for different O-glycans on the EGF repeats of the extracellular domain of Notch receptors, and important roles for complex N-glycans in models of tumor progression and spermatogenesis. Professor Stanley has been an Editorial Board Member for Scientific Reports since 2015.
Natascia Tiso is Associate Professor at the Department of Biology, University of Padova. Her main research interests are related to the analysis and modulation of signalling pathways involved in vertebrate development and human pathogenesis, exploiting the zebrafish as a model system. Professor Tiso has been an Editorial Board Member for Scientific Reports since 2018.
Maliha Zahid is a board-certified non-invasive Cardiologist and NIH funded Scientist who joined Mayo Clinic in August 2022, coming from University of Pittsburgh. Her areas of interest/expertise are cell penetrating peptides (also known as protein transduction domains), motile respiratory cilia and control of ciliogenesis via NOTCH manipulation. Dr. Zahid has been an Editorial Board Member for Scientific Reports since 2019.
