Nature Outlook |

Amyotrophic lateral sclerosis

Nature Outlook: Amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating disease with poorly understood causes and no known cure. But research is slowly beginning to bring hope to those affected. This Outlook discusses topics such as: how genetic and epidemiological research are beginning to reveal the secrets of ALS; new drugs and other treatments that are finally becoming available; and the lessons that the ALS Ice Bucket Challenge offers for funding disease research.

This Nature Outlook is editorially independent. It is produced with third party financial support. About this content.


For years, researchers missed the most common genetic cause of ALS. Now they're on an accelerated track to treat it.

Outlook | | Nature

Research ranging in scale from cells to populations is rapidly closing in on what goes awry in the body in 'non-familial' ALS, and what environmental factors might contribute.

Outlook | | Nature

Machine learning might identify patients earlier, predict their outcomes better, and assign them more efficiently to appropriate clinical trials.

Outlook | | Nature

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease predominantly affecting upper and lower motor neurons. Here, the authors outline previous and current efforts to characterize genes that are associated with ALS, and describe what is currently known about the genetic architecture of ALS.

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Article | Open Access | | Nature Communications

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