Cell death

Controlling cell death is crucial for the maintenance of organismal homeostasis, as both increased and insufficient cell death, and/or the elimination of dead cells, can have adverse effects on health. There are different modes of cell death, regulated and non-regulated. The Reviews in this series discuss our current understanding of the different cell death mechanisms; their crosstalk and interaction with other cellular pathways; their roles in physiology and human disease; and the potential of modulating cell death for therapeutic purposes.