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Biofilms are bacterial clusters embedded within an extracellular matrix that adhere both to each other and to cells throughout the body. An estimated 80% of chronic microbial infections across a range of tissues are thought to involve biofilms, with examples including chronic otitis media, recurrent urinary tract infection and endocarditis. Biofilm-related infections are particularly challenging to treat, given that their structure allows for evasion of the immune response and supports resistance to antibiotics. Development of new approaches to biofilm-related infection prevention, treatment and management is therefore critical.
This Collection gathers research that increases our understanding of the progression of biofilm-related infections and explores associated strategies for their diagnosis, prevention and treatment.