Sex differences in physiology and disease
Scientists and physicians have known for thousands of years that sex is a factor in physiology, pharmacology, and pathology. Nevertheless, despite a general understanding that sex differences are an important consideration in medicine and research, early efforts to reduce experimental variability - and improve clinical trial safety - resulted in preclinical and clinical studies primarily being conducted on same-sex, mostly male cohorts. However, there is increasing awareness that unexplored sex differences in research is limiting our understanding of drug mechanisms and disease progression.
This Collection explores the latest research considering the role that sex plays in both physiology and disease, and encourages studies that take these differences into account in their experimental design.
Editors
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Anthony Auger
University of Wisconsin-Madison, USA
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Maria Mavrikaki
Harvard Medical School & Beth Israel Deaconess Medical Center, USA
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Marianne Seney
University of Pittsburgh School of Medicine, USA
