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Oligodendrocytes, the myelinating cells of the central nervous system (CNS), play a crucial role in myelin generation, maintenance, and repair after CNS injuries and in demyelinating diseases. Beyond their myelin-related functions, recent studies have revealed additional roles for oligodendrocytes and their progenitors in synaptic plasticity and neuronal circuits. Moreover, growing evidence suggests that oligodendrocytes and myelin dysfunction contribute to the onset and progression of neurodegenerative diseases.
With this Collection, the editors at Nature Communications, Communications Biology and Scientific Reports welcome the submission of primary research articles that focus on oligodendrocytes lineage cells in development, physiology, and disease. We particularly encourage studies exploring their non-canonical roles and contribution to neurodegenerative diseases and other CNS disorders. We are also very interested in studies focusing on treatment strategies targeting oligodendrocytes and remyelination. This call welcomes both basic and preclinical studies in animal models, as well as studies involving human tissue.