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Autophagy and mitophagy are deregulated in many types of cancer stem cells (CSCs). Although there is yet to be discovered, both autophagy and mitophagy are able to regulate different steps of CSCs physiology such as metabolism, stemness, migration and chemo-resistance.
The induction and inhibition of autophagy may provide new strategies for intervening on major and specific diseases, respectively. The scheme provides an overview on pathologies that might be targeted by the manipulation of autophagy.
Vascular homeostasis relies on the proper behavior of endothelial cells (ECs). Emerging evidence indicate a critical role of autophagy, a vesicular process for lysosomal degradation of cytoplasmic content, in EC biology. While EC-intrinsic autophagy promotes EC function and quiescent state through redox homeostasis and possibly metabolic control, a role for EC-associated autophagy in cancer seems more complex.