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  • Collection |

    This Collection features our best recent content from CDDpress, which publishes forefront, innovative and international research covering the cell biology, molecular biology, and biochemistry of cell death and disease. Updated each month, this collection of articles includes content from all three CDDpress titles: Cell Death and Differentiation, Cell Death & Disease, and Cell Death Discovery.

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    The ability of cells to self-destruct appears to be essential for cellular life. However, the existence of genetically programmed death pathways in single-cell organisms has been long debated. Thus, cell death research on microorganisms was sparse while the field focused on human tumor cells, animal models and some plants. In addition, microbial death is most commonly viewed as a consequence of being killed by host immune tactics and antibiotics, rather than intrinsic microorganism cell suicide. However, a new perspective has recently emerged, stemming from elegant delineation of cell suicide mechanisms in diverse prokaryotic and eukaryotic microbes. The molecular details often resemble components of human innate immunity, further suggesting that some early forms of cell death arose in microorganisms as defense mechanisms against their own pathogens.

    Open for submissions

  • Collection |

    In this Collection we have collated the top read and cited articles from Cell Death & Differentiation from the past three years. This focus includes a spectrum of articles covering the cellular and molecular biology of disease and features original articles, as well as thought-provoking reviews and comment. Read on to see what our readers worldwide have been citing and reading.

  • Collection |

    In this Web Focus we have showcased the top read, shared and cited articles from Cell Death & Differentiation from 2018 and 2019. This collection includes a spectrum of articles covering the cellular and molecular biology of disease and features both original articles and thought-provoking reviews. We hope you enjoy reading this collection.

    Image: National Institutes of Health/Stocktrek Images

  • Collection |

    CDDpress, with its three journals (Cell Death & Differentiation, Cell Death & Disease, Cell Death Discovery), has just finished the publication for the year 2018, publishing insightful and high-impact articles on the frontlines of cell biology and biochemistry research. In 2018, the journals received nearly 5000 submissions and published around 1400 selected papers. Of particular interest were several pivotal and influential papers highlighting the role of p53 in cancer and other diseases. Here, with the "Best of CDDpress 2018 on p53" collection, we offer a selection of 2017-2018’s most impactful papers on p53. We hope that you will enjoy reading this special collection.

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    The recent 26th ECDO conference ‘From small molecules to translational medicine’ in Saint-Petersburg (locally organized by Professors Zhivotovsky, Barlev and Lavrik) highlighted the recent developments in the field of cell death with a focus on the small molecules discovery and development. Pharmacological targeting via small molecule-based chemical probes has recently emerged as a valuable tool to delineate molecular mechanisms of various cell death pathways and pave the way towards novel therapeutic approaches in cancer, neurodegenerative and autoimmune diseases. We suggest the selection of articles from the CDD press that will lead through a breathtaking journey from the target –oriented drug development to translational applications.

    Image: National Institutes of Health/Stocktrek Images

  • Collection |

    Autophagy is used by cells to deliver cytoplasmic material to lysosomes for degradation, and has been implicated in a wide variety of disorders, including cancer, neurodegeneration, infection and inflammatory diseases.

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    A web focus from Cell Death & Differentiation, Cell Death & Disease, Nature Reviews Cancer, Nature Cell Biology, Nature Reviews Molecular Cell Biology and Nature Structural & Molecular Biology. We hope you enjoy this focus including work from the world's most recognized experts in the field of autophagy.