Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A series of recent studies have established where the necroptosis machinery — RIPK1, RIPK3, MLKL, ZBP1 and Caspase-8 — occur and are activated in mouse and human tissues, and how ZBP1 splicing might regulate necroptosis. These studies highlight the importance of mapping necroptosis spatially to understand how pathway dysregulation can lead to disease.
In the recent Nature, Wang et al. and Zhong et al. present the cryo-EM structures of Gasdermin B (GSDMB) pore and strucures of GSDMB in complex with a Shigella effector, IpaH7.8. The structures shed light on the structural mechanisms that govern GSDMB-mediated pyroptosis, a process that is regulated by pathogenic bacteria and alternative splicing.