We recently reported a case study of chronic spinal cord injury (SCI), in which motor evoked potentials (MEPs) with normal amplitude and latency could be recorded from the extensor carpi radials (ECR) muscle, even though the motor power of this muscle was just 1/5.1
Calancie and Alexeeva2 have hypothesized that volume conduction from the unaffected brachioradialis (BR) muscle explains this observation, and suggested that this could be tested by recording the surface electromyography (EMG) from both muscles during a resisted elbow flexion with the forearm in mid-pronation and wrist relaxed.
We tested this hypothesis in the SCI participant from the original report. We observed strong EMG activity from the BR, whereas there was no EMG signal detected from the ECR (Figure 1). The root-mean-square EMG for BR was 97 μV compared to 4 μV for ECR (background noise level).
These results indicate that volume conduction from the BR does not explain our original report. The case study adds to previous literature3 that small, delayed MEPs can be recorded from weak muscles in people with SCI, by demonstrating that in some cases these MEPs can be remarkably normal.
References
Edwards DJ, Cortes M, Thickbroom GW, Rykman A, Pascual-Leone A, Volpe BT . Preserved corticospinal conduction without voluntary movement after spinal cord injury. Spinal Cord 2013; 51: 765–767.
Calancie B, Alexeeva N . Response to ‘Preserved corticospinal conduction without voluntary movement after spinal cord injury’. Spinal Cord, (e-pub ahead of print 22 July 2014; doi:10.1038/sc.2014.115).
Sherwood AM, Dimitrijevic MR, McKay WB . Evidence of subclinical brain influence in clinically complete spinal cord injury: discomplete SCI. J Neurol Sci 1985; 110: 90–98.
Acknowledgements
DJE, APL and MC were funded for this work by NIH grant R21HD077616.
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Edwards, D., Cortes, M., Thickbroom, G. et al. Reply: Evidence against volume conduction to explain normal MEPs in muscles with low motor power in SCI. Spinal Cord 52, 718 (2014). https://doi.org/10.1038/sc.2014.117
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DOI: https://doi.org/10.1038/sc.2014.117